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Development of IPS from Donated Somatic Cells of Patients with Neurological Diseases

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About this study

Human fibroblasts and possibly other human somatic cells may be reprogrammed into induced pluripotent stem (iPS) cells by the forced expression of transcription factors (1-5). The iPS cells seem to share many properties with human embryonic stem cells. Induced pluripotent stem cells potentially may be useful in the future as an unlimited source of cells for transplantation. The major goal of the project is to develop human iPS cells from cell cultures from skin biopsies or the patient's hair. The iPS cells will be developed primarily for modeling diseases and drug discovery as well as basic research, and for developing the technology that may eventually allow the use of iPS cells for future transplantation therapy. The iPS cells developed in the course of this application are not intended for use in transplantation therapy. Future development of iPS cells for clinical transplantation therapies will be subjected to the appropriate authorization by ethical and regulatory committees.

Condition
Neurodegenerative Disorders
Sponsor
Hadassah Medical Organization

Who can join

Age
18 years and older
Sex
All sexes
Healthy volunteers
Accepted

Inclusion 4

  • Minimum age: 18 years
  • Study condition: Neurodegenerative Disorders
  • Donors suffering from different (specified) neurodegenerative disorders scheduled to undergo surgery for medical reasons or will donate a single or a few hairs--to be removed intact from the scull or other areas in the body.
  • Healthy donors scheduled to undergo surgery for medical reasons or will donate a single or a few hairs--to be removed intact from the scull or other areas in the body.

Where

1 site, 1 recruiting

Hadassah Ein Kerem

Jerusalem, Israel, Israel

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.