Postoperative or Salvage Radiotherapy (RT) for Node Negative Prostate Cancer Following Radical Prostatectomy
About this study
The purpose of this study is to see what effects, good and/or bad, proton radiation, and/or conventional radiation and hormonal therapy (if applicable), has on prostate cancer that has already returned or the risk of prostate cancer returning.
- Condition
- Prostate Cancer
- Tested
- IMRT to 45 Gy; prostate bed proton boost of 21.6 CGE, Proton (prostate bed) to 70.2 CGE, IMRT to 45 Gy; proton boost to...
- Sponsor
- Proton Collaborative Group
Who can join
- Age
- 18 years and older
- Sex
- Male only
- Healthy volunteers
- Not accepted
Inclusion 5
- Minimum age: 18 years
- Eligible sex: Male
- Study condition: Prostate Cancer
- Prostate cancer treated primarily with open, laparoscopic or robotically assisted prostatectomy.
- Maximum PSA value of 20 ng/ml.
Exclusion 6
- Evidence of distant metastasis (M1).
- Prior systemic chemotherapy for any reason.
- Previous irradiation to the pelvis that would compromise the ability to deliver the prescribed study treatment.
- Active inflammatory bowel disease (Crohn's disease, diverticulitis or ulcerative colitis) affecting the rectum. (Non-active diverticulitis and Crohn's disease not affecting the rectum are allowed).
- Prior or concurrent cancer, other than non-melanomatous skin cancer, unless disease free for at least 5 years.
- Taking Saw Palmetto or methotrexate and unable or unwilling to discontinue its use during radiation.
Where
6 sites, 6 recruiting
Inova Schar Cancer Institute
Fairfax, Virginia, United States
McLaren Proton Therapy Center
Flint, Michigan, United States
University of Florida Proton Therapy Institute
Jacksonville, Florida, United States
Proton Center of Arkansas
Little Rock, Arkansas, United States
Mercy David C. Pratt Cancer Center
St Louis, Missouri, United States
Northwestern Medicine Chicago Proton Center
Warrenville, Illinois, United States
Potential match only. Final eligibility is determined by the study team.