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Recruiting Phase 3

The Cancer of the Pancreas Screening-5 CAPS5)Study

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About this study

Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.

Condition
Pancreas Cancer, Peutz-Jeghers Syndrome (PJS), Gene Mutation, Germline Mutation Carrier, Lynch Syndrome
Tested
Secretin, MRI, Tumor marker gene test with CA19-9
Sponsor
Johns Hopkins University

Who can join

Age
18 years and older
Sex
All sexes
Healthy volunteers
Not accepted

Inclusion 7

  • Minimum age: 18 years
  • Study condition: Pancreas Cancer, Peutz-Jeghers Syndrome (PJS), Gene Mutation, Germline Mutation Carrier, Lynch Syndrome
  • Hereditary Pancreatitis or
  • Peutz-Jeghers Syndrome or
  • Strong family history of pancreas cancer on one side of the family tree or
  • Confirmed germline mutation carrier (BRCA2, FAMMM (CDKN2A/p16), PALB2, BRCA1, ATM, HNPCC, Lynch Syndrome (hMLH1, hMSH2, PMS2, hMSH6, EpCAM) PRSS1, PRSS2, R122H, N291l, SPINK1, CFTR
  • Endoscopic evaluation of pancreas scheduled

Exclusion 6

  • Medical comorbidities or coagulopathy that contraindicate endoscopy
  • Prior surgery that prevent optimal endoscopic ultrasound such as partial or complete gastrectomy with Bilroth or Roux-en-Y anastomosis
  • Stricture or obstruction in the upper GI tract that does not allow passage of the echoendoscope
  • Poor performance status
  • Inability to provide informed consent
  • Pregnancy.

Where

9 sites, 9 recruiting

University of Michigan

Ann Arbor, Michigan, United States

Recruiting

Johns Hopkins Hospital

Baltimore, Maryland, United States

Recruiting

Dana Farber Cancer Center, Harvard University

Boston, Massachusetts, United States

Recruiting

Case Comprehensive Cancer Center, Case Western Medical Reserve

Cleveland, Ohio, United States

Recruiting

Yale University

New Haven, Connecticut, United States

Recruiting

Columbia University Medical Center

New York, New York, United States

Recruiting

and 3 more sites on ClinicalTrials.gov

Contact

Potential match only. Final eligibility is determined by the study team.