Skip to content
TrialMatch
Sign up
Recruiting

Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease

Create a profile to match View the full record on ClinicalTrials.gov

About this study

In AD (Alzheimer disease), the anatomic correlates of attention disorders (as evaluated by motor slowing) have not been thoroughly characterized.

Condition
Alzheimer Disease
Tested
Brain MRI, neuropsychological evaluation, Blood
Sponsor
Centre Hospitalier Universitaire, Amiens

Who can join

Age
40 to 85 years
Sex
All sexes
Healthy volunteers
Accepted

Inclusion 14

  • Minimum age: 40 years
  • Maximum age: 85 years
  • Study condition: Alzheimer Disease
  • Patients
  • Age between 40 and 85
  • French mother tongue
  • Consulting at the Amiens Memory Resource and Research Centre (CMRR) for:
  • MCI, according to Albert et al.'s criteria (Albert et al., 2011)
  • Mild dementia (MMSE\>20) due to AD, according to McKhann's criteria (McKhann et al., 2011).
  • Mild dementia due to LBD, according to McKeith et al.'s criteria (McKeith et al., 2005).
  • Mild dementia due to FTLD, according to Rascovsky et al.'s criteria (Rascovsky et al., 2011).
  • Social security coverage
  • Healthy controls
  • Healthy age and gender matched volunteers will be recruited into the study from the general population.

Exclusion 24

  • Reading or writing difficulties related to a learning disorder or illiteracy.
  • A medical history with a potentially significant impact on cognition (non-corrected thyroid disorders or heart failure):
  • NYHA stage IV dyspnoea.
  • respiratory impairment requiring oxygen therapy.
  • liver impairment.
  • kidney failure, progressing neoplastic disease, or past or present alcohol abuse.
  • Past or present neurological disorders other than those having prompted consultation in the Memory Clinic:
  • stroke.
  • meningitis or encephalitis.
  • severe head injury.
  • sensorimotor impairments (sensory, proprioceptive, cerebellar and visual impairments).
  • epilepsy (requiring ongoing treatment),
  • psychiatric disorders (other than treated depression).
  • treatment with psychotropic medications (other than anxiolytics or antidepressant withdrawn or initiated in the previous month). Patients with parkinsonian syndrome were examined in the "on-drug" state.
  • Impossibility to perform a neuropsychological evaluation or brain MRI.
  • Withdrawal from the study at any time, if desired.
  • Pregnancy
  • Contra-indication to MRI:
  • nerve stimulators
  • cochlear implants
  • ferromagnetic foreign bodies close to nervous structures in the eye or brain
  • cerebral shunts
  • dental appliances
  • Legal guardianship or incarceration.

Where

1 site, 1 recruiting

CHU Amiens

Amiens, France

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.