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Nanshan Elderly Cohort Study

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About this study

Objective: The Nanshan Elderly Cohort Study (NECS) aims to investigate the nutritional, as well as other environmental and genetic factors of chronic diseases, such as cardio-metabolic diseases. Study design: NECS is a community-based prospective cohort study. Participants: About 10000-20000 apparently healthy residents, living in Nanshan， Shenzhen (South China) for \>5 years, aged ≥ 65 years, will be recruited between 2018 and 2019. Visits and Data Collection: Participants will be followed up approximately every 3 years by invited to the Community Healthcare Service Centre. At each survey, face-to-face interviews, anthropometric measurements, ultrasonography examination, electrocardiogram test and specimen collection will be conducted. Key variables: 1. Face-to-face interviews: Structured questionnaires will be used to collect the participants' socio-demographic characteristics, lifestyles, habitual dietary intake, physical activity, history of chronic diseases, use of supplements and medications, family history, psychological health and cognitive function. 2. Physical examinations: Anthropometric measurements, blood pressure tests, handgrip strength, and usual gait speed. 3. Ultrasonography examinations: Ultrasonography examination will be performed to determine carotid artery intima-media thickness and plaque, fatty liver. 4. Electrocardiogram test: Electrocardiogram test is to obtain information about the structure and function of the heart. 5. Specimen collections: Overnight fasting blood sample, early morning first-void urine sample and faeces samples will be collected and stored at -80°C till tests. 6. Laboratory tests: 1. Blood tests: Metabolic syndrome-related indices; nutritional indices; inflammatory markers; sexual hormones; genetic markers. 2. Urinary tests: Flavonoids and flavones, minerals, creatinine and renal function related markers. 3. Fecal test: Gut microbiota and related metabolites. 7. Morbidity and mortality: Relevant data will be also retrieved via local multiple Health information systems. 8. Others: Many other laboratory tests or instrument tests will be developed depended on needs and resources in future.

Condition
Hypertension, Type 2 Diabetes Mellitus, Cardiovascular Diseases, Stroke, Obesity, Metabolic Syndrome, Sarcopenia, Chronic Kidney Disease, Cancer, Death
Sponsor
Sun Yat-sen University

Who can join

Age
65 years and older
Sex
All sexes
Healthy volunteers
Accepted

Inclusion 5

  • Minimum age: 65 years
  • Study condition: Hypertension, Type 2 Diabetes Mellitus, Cardiovascular Diseases, Stroke, Obesity, Metabolic Syndrome, Sarcopenia, Chronic Kidney Disease, Cancer, Death
  • Age: ≥ 65 years;
  • Living in Nanshan, Shenzhen for at least 5 years;
  • Chinese.

Exclusion 5

  • Had a history of hospital-confirmed diabetes, failure(s) of heart, liver, or kidney, cancer, CVD events;
  • On special diet due to a disease or weight control;
  • Mental and physical disability;
  • Likely to move to other city within 5 years;
  • Did not want to attend any one item of the survey or sample collection.

Where

2 sites, 1 recruiting

Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control

Shenzhen, Guangdong, China

Recruiting

Department of Medical Statistics & Epidemiology, School of Public Health, Sun Yat-sen University

Guangzhou, China

Contact

Potential match only. Final eligibility is determined by the study team.