Correlation Study Between Clinical Phenotype and Pathology of Type 2 Diabetic Nephropathy
About this study
With the rapid increase of diabetic nephropathy worldwide, type 2 diabetes mellitus(DM) is the leading cause of end-stage renal disease(ESRD). Pathological types of diabetic kidney disease(DKD) could be mainly divided into diabetic nephropathy（DN）and non-diabetic renal diseases（NDRD）. There are no accurate renal biopsy indications and standardized operation procedures for type 2 diabetic nephropathy. The clinical stages of type 2 diabetic nephropathy still referred to the Mogensen stage of type 1 diabetic nephropathy. Thus, our study aim to clarify the differences in clinical phenotype between type 2 DN and type 2 NDRD, analysis the correlation between clinical and pathological features, and offer the criteria for clinical staging and prognosis.
- Condition
- Diabetic Kidney Disease
- Sponsor
- Chinese PLA General Hospital
Who can join
- Age
- 18 years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 7
- Minimum age: 18 years
- Study condition: Diabetic Kidney Disease
- Age≥18, male or female
- Clinical diagnosed as type 2 diabetes mellitus
- The presence of renal impairment including: microalbuminuria or overt proteinuria or renal insufficiency
- The renal biopsy was performed with complete renal pathological diagnosis
- Obtaining the signed informed consent from patients
Exclusion 6
- The history of the disease was not complete
- Clinical diagnosed as other secondary renal diseases
- Patients with hereditary kidney disease
- Autoimmune diseases
- Patients with malignant tumor were expected to survive less than 6 months
- Pregnancy and lactation
Where
1 site, 1 recruiting
Chinese PLA General Hospital
Beijing, Beijing Municipality, China
Contact
-
Xiangmei Chen, MD.&Ph.D
+86 010 66935462 xmchen301@126.com
-
Zheyi Dong, MD.&Ph.D
+86 010 66935462 shengdai26@163.com
Potential match only. Final eligibility is determined by the study team.