Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention
About this study
The study is aimed * To quantify the change of adipose tissues, triglyceride in liver and pancreas and cholesterol after lifestyle intervention or bariatric surgery. * To test the hypothesis that Brown fat is an independent biomarker for the development of Non Alcoholic Fat Liver Disease (NAFLD) * To study the association among Brown fat, NAFLD and obesity.
- Condition
- Non-Alcoholic Fatty Liver Disease, Obesity, Morbid, Brown Fat, Metabolic Disease, Diabetes Mellitus, Insulin Resistance, Abdominal Subcutaneous Fat
- Tested
- Bariatric surgery, Dietitian led life style modification intervention, Conventional care (control)
- Sponsor
- Chinese University of Hong Kong
Who can join
- Age
- 18 to 65 years
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 6
- Minimum age: 18 years
- Maximum age: 65 years
- Study condition: Non-Alcoholic Fatty Liver Disease, Obesity, Morbid, Brown Fat, Metabolic Disease, Diabetes Mellitus, Insulin Resistance, Abdominal Subcutaneous Fat
- BMI ≥ 25-30 kg/m2
- BMI ≥ 30 kg/m2 with Metabolic syndrome
- BMI ≥ 35 kg/m2 for morbid obesity
Exclusion 5
- Other kind of hepatic diseases
- Under medications known to affect liver fat
- Waist circumference ≥ 150 cm
- Weight ≥ 250 kg
- MRI contraindications
Where
1 site, 1 recruiting
The Chinese University of Hong Kong, Prince of Wale Hospital
Hong Kong, Shatin, Hong Kong
Contact
-
Winnie C Chu, MD
(852) 3505 2299 winniechu@cuhk.edu.hk
Potential match only. Final eligibility is determined by the study team.