Gut Microbiome Dynamics in Metastasized or Irresectable Colorectal Cancer
About this study
In this study the characteristics and alterations of the gut microbiome during chemotherapy for metastasized or irresectable CRC are studied, as well as the relation between the gut microbiome and the effects of chemotherapy.
- Condition
- Colorectal Cancer Metastatic
- Tested
- fecal sample, questionnaire, Blood sample
- Sponsor
- University Medical Center Groningen
Who can join
- Age
- 18 years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 9
- Minimum age: 18 years
- Study condition: Colorectal Cancer Metastatic
- Age ≥ 18 years
- Patients with histologically confirmed CRC with an indication for palliative systemic anti-tumor therapy (ANY combination of chemotherapy with/without anti-VEGF of anti-EGFR therapy)
- Measurable disease according to RECIST v1.1.
- Stored pathological specimens available
- Life expectancy ≥ 12 weeks
- Signed Informed Consent Form
- Ability to comply with protocol
Exclusion 5
- Previous (neo)adjuvant chemotherapy \< 6 months
- Previous radiotherapy on the small or large intestine \< 1month
- Previous surgery of the small or large intestine \< 1 month
- Uncontrolled inflammatory bowel disease
- Participation in a study with a potential effect on the gut microbiome
Where
10 sites, 10 recruiting
Wilhelmina Ziekenhuis
Assen, Netherlands
Ziekenhuis Nij Smellinghe
Drachten, Netherlands
Treant Zorggroep
Emmen, Netherlands
Medisch Spectrum Twente
Enschede, Netherlands
University Medical Center Groningen
Groningen, Netherlands
Martini Ziekenhuis
Groningen, Netherlands
and 4 more sites on ClinicalTrials.gov
Contact
-
J. J. de Haan, MD, PhD
+31 50 3612821 j.j.de.haan@umcg.nl
-
D. J. de Groot, MD, PhD
+31 50 361 2821 d.j.a.de.groot@umcg.nl
Potential match only. Final eligibility is determined by the study team.