Recruiting
Phase 1 / Phase 2
RH Genotype Matched RBC Transfusions
About this study
To determine the feasibility and efficacy of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.
- Condition
- Sickle Cells Disease
- Tested
- Red cell units that are genotype matched at the RHD and RHCE loci
- Sponsor
- Children's Hospital of Philadelphia
Who can join
- Age
- 0.5 years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 6
- Minimum age: 0.5 years
- Study condition: Sickle Cells Disease
- Subjects age \>6 months
- Diagnosis of SCD, all genotypes
- Require a period of chronic red cell transfusion therapy
- Subject/parental/guardian permission (informed consent) and if appropriate, child assent
Exclusion 5
- Rare RH genotype that would preclude identification of sufficient RBC units
- Antigen negative requirements due to alloimmunization that would preclude identification of sufficient RBC units
- Alloimmunized to D antigen
- Rh alloimmunized patients for whom providing RH genotype matched blood would expose the patient to an antigen that would not be consistent with standard of care and blood bank protocols
- Parents/guardians or subjects who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures
Where
1 site, 1 recruiting
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Contact
-
Stella Chou, MD
215-590-0947 chous@chop.edu
Potential match only. Final eligibility is determined by the study team.