Exercise and Cognitive (Brain) Function in Breast Cancer Patients Getting Chemotherapy After Breast Surgery
About this study
This study will primarily identify longitudinal associations between cardiorespiratory fitness (CRF) and cognitive function pre- (baseline) to post-chemotherapy (\~3 months). This will be a prospective study of 50 BCS. We hypothesize that breast cancer patients undergoing chemotherapy who have higher levels of CRF at baseline will have significantly improved measures of attention, executive function, and memory post-chemotherapy. In addition, the exploratory aims will examine the longitudinal associations between physical activity (PA) and cognitive function from pre- to post-chemotherapy and explore the associations between inflammatory and non-inflammatory biomarkers and CRF with cognitive function.
- Condition
- Breast Cancer
- Sponsor
- University of Toronto
Who can join
- Age
- 18 to 65 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
Inclusion 7
- Minimum age: 18 years
- Maximum age: 65 years
- Eligible sex: Female
- Study condition: Breast Cancer
- 18-65 years old
- histologically-confirmed stage I-III breast cancer, but prior to the initiation of chemotherapy (\<1 cycle of adjuvant therapy or neoadjuvant therapy)
- no diagnosed major cognitive disorders and uncontrolled comorbidities.
Exclusion 2
- received neoadjuvant chemotherapy and scheduled to receive adjuvant chemotherapy
- scheduled to receive concurrent radiation therapy with chemotherapy.
Where
1 site, 1 recruiting
Sunnybrook Health Sciences Centre-Odette Cancer Centre
Toronto, Ontario, Canada
Contact
-
Linda Trinh, PhD
(416) 946-3624 linda.trinh@utoronto.ca
Potential match only. Final eligibility is determined by the study team.