Accelerated Partial Breast Irradiation Versus Standard or Hypofractionated Whole-Breast Irradiation, in Early Breast Cancer, After Breast-conserving Surgery
About this study
Radiotherapy has been confirmed as an important treatment breast-conserving surgery reducing the risk of any recurrence of breast cancer and breast cancer-related mortality in patients with early breast cancer. There are no comparative data on the ideal radiotherapy treatment regimen for patients with early stage breast cancer who underwent conservative surgery in the Brazilian population.
- Condition
- Malignant Neoplasm of Breast
- Tested
- Active Comparator: Standard, Experimental 1: Hypofractionated radiotherapy, Experimental 2: Accelerated Partial Breast I...
- Sponsor
- Instituto Brasileiro de Controle do Cancer
Who can join
- Age
- 50 to 90 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
Inclusion 17
- Minimum age: 50 years
- Maximum age: 90 years
- Eligible sex: Female
- Study condition: Malignant Neoplasm of Breast
- Information to the patient and signed informed consent;
- Women aged ≥50 years
- Breast conserving surgery
- Pathologic tumor size \< 3 cm (maximum microscopic diameter of the invasive component)
- Invasive adenocarcinoma (except classic invasive lobular carcinoma)
- Unifocal disease
- Histopathologic grades I or II
- Eastern Cooperative Oncology Group (ECOG) 0-1
- Lymphovascular invasion absent
- Negative axillary lymph nodes
- Minimum microscopic margins of non-cancerous tissue of 2mm (excluding deep margin when in deep fascia)
- No prior breast or mediastinal radiotherapy
- No hematogenous metastases
Exclusion 9
- Previous malignancy (except non-melanomatous skin cancer)
- Mastectomy
- Classical-Type Invasive Lobular Carcinoma
- Neoadjuvant chemotherapy
- Human Epidermal growth factor Receptor-type 2 positive (HER2+)
- Triple-negative breast cancers
- Intravascular lymphoma present
- Contraindications to radiotherapy.
- No geographical, social or psychologic reasons that would prevent study follow
Where
1 site, 1 recruiting
IBCC Oncologia
São Paulo, São Paulo, Brazil
Contact
-
Eduardo Barbieri
+551198639-1945 edurxt@gmail.com
-
Alayne D Yamada, PhD
+55113474-4242 alayne.pesquisa@ibcc-mooca.org.br
Potential match only. Final eligibility is determined by the study team.