Detection of Alzheimer's Disease (AD)-Related Seeds for AD Diagnosis
About this study
The study will investigate the biomarkers of Aβ and Tau seeds in plasma detected by Alzheimer's disease (AD) related seeds quantitative detector (AD-seeds-detector), and their sensitivity and specificity in diagnosing AD, compared with those from age-matched cognitively normal controls, and those with other types of dementia. To perform a high throughput analysis of the amount of Aβ and Tau seeds, the investigators have developed an AD-seeds-detector, in which a fluorescence microplate reader was combined with an oscillating mixer or water-bath-type ultrasonicator.
- Condition
- Alzheimer's Disease
- Sponsor
- Capital Medical University
Who can join
- Age
- 55 to 75 years
- Sex
- All sexes
- Healthy volunteers
- Accepted
Inclusion 7
- Minimum age: 55 years
- Maximum age: 75 years
- Study condition: Alzheimer's Disease
- Written informed consent obtained from participant or legal guardian prior to any study-related procedures.
- The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.
- As for non-AD dementia, the McKeith criteria are used for DLB,the revised diagnostic criteria proposed by the International behavioral variant (bvFTD) Criteria Consortium for bvFTD,the Gorno-Tempini criteria for the semantic variant FTD or non-fluent aphasia, the Movement Disorder Society Task Force criteria for PDD, the vascular behavioral and cognitive disorders (Vas-Cog) criteria for VaD, the Armstrong's criteria for CBD, the CDC's diagnostic criteria for CJD, etc.
- In addition, normal cognition is supported by MMSE, CDR and other cognitive function scales.
Exclusion 1
- Other medical or psychiatric illness. No one can serve as an informant. Refused to complete a cognitive test and provide biospecimen.
Where
1 site, 1 recruiting
Xuanwu Hospital of Capital Medical University
Beijing, Beijing Municipality, China
Contact
-
Jianping Jia, Doctor
8610-83199449 jiajp@vip.126.com
Potential match only. Final eligibility is determined by the study team.