DETECT: Target Volume for Rectal Endoluminal Radiation Boosting
About this study
The aim of the study is to provide prospective data regarding microscopic tumor spread in all directions from the macroscopic tumor in pathology specimens, as seen by eye, and on imaging to define the target volume for endoluminal radiation boosting in rectal cancer patients.
- Condition
- Rectal Cancer
- Tested
- Ultrasound, Rectoscopy, Scan, e.g. CT (resection specimen)
- Sponsor
- Maastricht Radiation Oncology
Who can join
- Age
- 18 years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 7
- Minimum age: 18 years
- Study condition: Rectal Cancer
- ≥18 years of age and capable of giving informed consent.
- ycT1-3N0(\*) residual(\*\*) histology confirmed rectal adenocarcinoma after neoadjuvant radiotherapy or long-course chemoradiotherapy for which patients will undergo TME surgery.
- Minimal interval between end of neoadjuvant chemoradiotherapy or radiotherapy: 6 weeks.
- (\*)= as determined by clinical assessment (digital rectal examination, endoscopy with or without biopsy) and/or MRI. Biopsy/histology around the time of diagnosis is adequate; no biopsy/histology is needed after neoadjuvant therapy.
- (\*\*)= including tumor regrowths/local recurrence after an initial clinical complete response and a "watch and wait" approach. These patients will also be included after the local recurrence has been determined using endoscopy and/or MRI.
Exclusion 5
- Patient has received brachytherapy as part of neoadjuvant treatment.
- \<18 years of age or incapable of giving informed consent.
- Patient has not been treated with neoadjuvant radiotherapy or long-course chemoradiotherapy.
- Patient will not undergo TME surgery for a ycT1-3N0 residual histology confirmed rectal adenocarcinoma.
- Interval between end of neoadjuvant therapy and surgery is \<6 weeks.
Where
3 sites, 3 recruiting
Catharina Hospital
Eindhoven, North Brabant, Netherlands
Maastro
Maastricht, Limburg, Netherlands
Maastricht University Medical Center
Maastricht, Limburg, Netherlands
Contact
-
Maaike Berbée, MD, PhD
0031884455600 maaike.berbee@maastro.nl
-
Evert Van Limbergen, MD, PhD
0031884455600 evert.vanlimbergen@maastro.nl
Potential match only. Final eligibility is determined by the study team.