Reducing African American's Alzheimer's Risk Through Exercis...

About this study

The RAATE-MCI proposal is designed to determine the effects of physical activity on risk factors for Alzheimer's Disease in older African American adults. The study will compare a physical activity program to an active control group. RAATE-MCI is a 52-week randomized controlled trial. 144 African American adults aged 60 and older will be recruited.

Condition: Dementia of Alzheimer Type
Tested: Physical activity program, Successful Aging
Sponsor: Pennington Biomedical Research Center

Who can join

Age: 60 years and older
Sex: All sexes
Healthy volunteers: Not accepted

Inclusion 16

Minimum age: 60 years
Study condition: Dementia of Alzheimer Type
are African American (self-identify)
are 60 and older
are physically capable of exercise
are willing to accept randomization
are willing to attend group sessions
plan to live in the study area over the next 13 months and capable of traveling to designated study facility for clinic visits and intervention sessions for the next year
are free of conditions (e.g. uncontrolled asthma, severe sickle cell disease, etc.) that would make regular exercise unsafe as deemed by the medical investigator
have not engaged in regular physical activity
have a Short Physical Performance Battery ≥4
physically capable of exercise
are unable to utilize devices and/or applications as required for study participation
willing to attend group sessions
willing to allow researchers to use data for research purposes after study participation is completed
meet criteria for MCI as defined by the NIA-AA research framework a. cognitive performance below normal range (score \< 1.5 SDs below the mean on NIH Toolbox scores for their age and sex on at least one of the subtests)

Exclusion 17

have cognitive impairment that would interfere with participating in a group discussion
a. cognitive performance in the demented range (score \< 3 SDs below the mean on NIH Toolbox scores for their age and sex on at least one of the subtests)
meet criteria for dementia
are unwilling to give written informed consent or accept randomization in either study group
are too active (as defined by ≥10 min bouts of MVPA as measured by Actigraph) if:
Sum of MVPA bouts for the 7 day wear period ≥40 mins
Or ≤40 mins of MVPA 10min bouts AND ≥3 days of bouts
have uncontrolled hypertension (systolic blood pressure \> 150 mmHg and/or diastolic blood pressure \> 90 mmHg).
have had a myocardial infarction, major heart surgery (i.e., valve replacement or bypass surgery), stroke, deep vein thrombosis, pulmonary embolus, hip fracture, hip or knee replacement, or spinal surgery in the past 6 months
are undergoing cardiopulmonary rehabilitation
have uncontrolled diabetes that in the judgment of the MI may interfere with study participation
have clinically diagnosed osteoporosis that in the judgment of the MI may interfere with study participation
are currently enrolled in another randomized trial involving lifestyle or pharmaceutical interventions
have another member of the household that is a participant in RAATE or RAATE MCI
refuse to participate in the study without disclosure of their amyloid PET scan results
refuse to allow anonymized versions of their study data for research after this study is completed.
have other medical, psychiatric, or behavioral factors that in the judgment of the Principal or Medical Investigator may interfere with study participation or the ability to follow the intervention protocol

Where

1 site, 1 recruiting

Pennington Biomedical Research

Baton Rouge, Louisiana, United States

Recruiting

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