Late Onset Alzheimer's Disease
About this study
The goal of this study is to is to focus on the genetic influences on Alzheimer's Disease (AD) risk. The investigators are looking for families and/or individuals (affected or unaffected) of any ethic background (African American, Caucasian, and Hispanics) with a family history of AD and willing to participate.
- Condition
- Alzheimer Disease
- Tested
- Blood Draw, Late Onset Alzheimer's Disease (LOAD) Neuropsychological Battery Test
- Sponsor
- Columbia University
Who can join
- Age
- 55 years and older
- Sex
- All sexes
- Healthy volunteers
- Accepted
Inclusion 7
- Minimum age: 55 years
- Study condition: Alzheimer Disease
- Established diagnosis of definite or probable AD or have a diagnosis of a related neurodegenerative disorder such as Frontotemporal Dementia (FTD) or Lewy Body Dementia (LBD) (will also recruit sporadic FTD and LBD) cases.
- a living sibling with probable or possible AD;
- a third living relative affected with AD (onset age 50 or older) or unaffected (60 or older);
- participants in the proband's generation with an identified companion serving as an informant;
- participants who have capacity to consent or participants lacking capacity to consent with a surrogate/proxy in place to provide consent.
Exclusion 6
- failure to identify an appropriate informant;
- uncertainty of the clinical diagnosis of Alzheimer's disease or other related disorder;
- discovery of additional diagnosis that could account for the clinical manifestations;
- unwillingness to participate;
- failure to identify a living sibling with AD or other related disorder (except in the cases of sporadic FTD and sporadic LBD);
- participants lacking the capacity to consent who do not have a surrogate or proxy or next of kin to provide consent.
Where
12 sites, 12 recruiting
Rush University
Aurora, Illinois, United States
Indiana University
Bloomington, Indiana, United States
University of Texas Southwestern
Dallas, Texas, United States
NCRAD at Indiana University
Indianapolis, Indiana, United States
University of Miami
Miami, Florida, United States
Columbia University Irving Medical Center
New York, New York, United States
and 6 more sites on ClinicalTrials.gov
Contact
-
Dolly Reyes-Dumeyer
212-305-5953 dr2290@cumc.columbia.edu
-
Amanda Chan
917-696-3082 akc2177@cumc.columbia.edu
Potential match only. Final eligibility is determined by the study team.