Skip to content
TrialMatch
Sign up
Recruiting

Phase 2 - Rhythmic Light Therapy for Alzheimer's Disease Patients

Create a profile to match View the full record on ClinicalTrials.gov

About this study

Participants will randomly be placed into one of four groups and experience one of the four following conditions: (1) a placebo light that provides a 40 hertz (Hz) flicker (rhythmic light \[RL\]); (2) a placebo light with a random flicker (placebo condition for rhythmic light); (3) a light source that will stimulate the circadian system and provides a 40 Hz flicker (RL); or (4) a light source that will stimulate the circadian system and provides a random flicker (placebo condition for rhythmic light). Following a baseline week, participants will experience his/her assigned lighting condition for two hours in the morning for 8 weeks. After a 4-week washout period, a final round of assessments will be obtained. Study assessments (except for the Pittsburgh Sleep Quality Index and Montreal Cognitive Assessment) will be collected at the end of each week, for a total of 8 assessments.

Condition
Mild Cognitive Impairment
Tested
Circadian-Effective Light, Rhythmic Light, Placebo Light, Placebo Rhythmic Light
Sponsor
Icahn School of Medicine at Mount Sinai

Who can join

Age
55 years and older
Sex
All sexes
Healthy volunteers
Not accepted

Inclusion 5

  • Minimum age: 55 years
  • Study condition: Mild Cognitive Impairment
  • Participants must be diagnosed with mild cognitive impairment or mild Alzheimer's disease, as defined by a Montreal Cognitive Assessment score between 17 and 25;
  • Have sleep disturbance indicated by a score \>5 on the Pittsburgh Sleep Quality Index
  • Participants must reside in their homes, independent living, or assisted living facilities

Exclusion 5

  • Participants taking sleep medication
  • Residence in a skilled nursing facility or long-term care
  • Obstructing cataracts, macular degeneration, and blindness
  • Severe sleep apnea or restless leg syndrome
  • History of severe epilepsy

Where

2 sites, 2 recruiting

Light and Health Research Center

Menands, New York, United States

Recruiting

Icahn School of Medicine at Mount Sinai

New York, New York, United States

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.