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R-CDOP Regimen in the Treatment of Newly Diagnosed Non-Hodgkin's Lymphoma With High Tumor Burden

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About this study

A single-center, prospective clinical study to evaluate the efficacy and safety of R-CDOP (Rituximab, Cyclophosphamide, Doxorubicin hydrochloride liposome, Vindesine, Prednisone ) in the treatment of newly diagnosed high tumor burden non-Hodgkin's lymphoma, which has previously shown promising efficacy.

Condition
Diffuse Large B Cell Lymphoma, Follicular Lymphoma Grade 3B
Tested
R-CDOP
Sponsor
oubai, MD/PhD

Who can join

Age
18 to 75 years
Sex
All sexes
Healthy volunteers
Not accepted

Inclusion 18

  • Minimum age: 18 years
  • Maximum age: 75 years
  • Study condition: Diffuse Large B Cell Lymphoma, Follicular Lymphoma Grade 3B
  • Histologically immunohistochemistry and imaging confirmed diffuse large B-cell lymphoma or follicular lymphoma grade 3B;
  • Has at least one evaluable or measurable lesion according to Lugano response criteria;
  • Patients with at least one of the following high tumor burden Involvement of at least 3 nodal sites (each with a diameter greater than 3 cm); nodal or extranodal mass \> 7cm in its greater diameter;
  • Hepatomegaly and splenomegaly (infiltration confirmed by PET-CT;
  • Spleen: female \> 15cm, male \> 16cm);
  • Pleural/peritoneal effusion;
  • Lactate dehydrogenase (LDH) three times the upper limit of normal;
  • PET-CT TMTV \>220cm3;
  • Patients previously untreated;
  • Patients aged over 18 and under 75 years;
  • Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0\~2;
  • International Prognostic Index (IPI) score \> 1, or with extranodal mass diameter ≥7cm;
  • Life expectancy ≥ 6 months;
  • Left Ventricular Ejection Fraction (LVEF) ≥ 50%;
  • Patients must sign informed consent and be willing and able to comply with the requirements of visits, treatment, laboratory tests and other research requirements stipulated in the research schedule.

Exclusion 12

  • Pregnant or lactation and patients of childbearing age who do not want to take contraceptive measures;
  • Abnormal liver function \[total bilirubin \> 1.5 times of the upper limit of normal value;
  • Alanine aminotransferase/Aspartate aminotransferase (ALT / AST) \> 2.5 times of upper limit of normal value for patients without liver metastasis ;
  • ALT / AST \> 5 times of upper limit of normal value for patients with liver metastasis \], abnormal renal function (serum creatinine \> 1.5 times of upper limit of normal value) ;
  • Absolute Neutrophil Count (ANC)\<1.5×10\^9/L or Platelet (PLT)\< 75 × 10\^9/L;
  • Hypersensitivity to any study drug or its ingredients;
  • Patients with significant and uncontrolled cardiovascular disease or history;
  • Persons with mental disorders/unable to obtain informed consent;
  • Lymphoma infiltrates the central nervous system;
  • Previous history of malignant tumor;
  • HIV infection; HBV infection (HBV-DNA\> 2000 IU/ml);HCV infection (HCV-RNA\>200 IU/ml);
  • The investigator determined not suitable to participate in this study.

Where

1 site, 1 recruiting

The First Bethune Hospital of Jilin University

Changchun, Jilin, China

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.