Hyperpolarized 129-Xenon Imaging in Adult Hematopoietic Cell Transplant Recipients With Pulmonary Impairment
About this study
This study is designed to measure the correlation of hyperpolarized 129-Xe magnetic resonance imaging (129-XeMRI) in allogeneic hematopoietic cell transplant (allo-HCT) recipients at MD Anderson Cancer Center (MDACC) who develop bronchiolitis obliterans syndrome (BOS) or BOS stage 0p (pulmonary impairment not meeting the definition for BOS, defined below) and controls with chronic graft-versus-host disease (cGVHD). The primary objective of the study is to correlate 129-Xenon measures of ventilation, gas exchange, and pulmonary circulation with spirometric and quantitative CT measurements. A secondary objective is to determine whether measurement of 129-Xe MRI characteristics in patients with BOS stage 0p can predict BOS progression 6 months after enrollment.
- Condition
- Pulmonary, Pneumonia, Hematopoietic System--Cancer
- Tested
- 29-XeMRI imaging
- Sponsor
- M.D. Anderson Cancer Center
Who can join
- Age
- 18 years and older
- Sex
- All sexes
- Healthy volunteers
- Accepted
Inclusion 7
- Minimum age: 18 years
- Study condition: Pulmonary, Pneumonia, Hematopoietic System--Cancer
- \- Allo-HCT recipients who are at least 18 years of age and have BOS (n=10 patients), BOS 0p (n = 10 patients), or cGVHD of a non-lung organ without evidence of pulmonary impairment (n = 5 patients).
- Healthy Cohort - Inclusion Criteria:
- We will perform only XeMRI imaging on 10 healthy adult (18 years and older) volunteers with no medical issues for technical calibration of the XeMRI technology.
- Members of the study team may serve as healthy volunteers if they have no prior history of lung disease.
- These data will not be included as part of the analysis.
Exclusion 6
- Participants unable to follow up at MD Anderson for routine clinical care
- Inability or unwillingness to give informed consent
- Relapsed disease or life expectancy less than 6 months at time of enrollment
- Severe claustrophobia precluding MRI imaging
- Active pulmonary infection
- Pregnant women
Where
1 site, 1 recruiting
M D Anderson Cancer Center
Houston, Texas, United States
Contact
-
Ajay Sheshadri
(713) 563-1987 asheshadri@mdanderson.org
Potential match only. Final eligibility is determined by the study team.