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Feasibility Study to Investigate Rectal Mucus in Aero-Digestive Tract Cancer.

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About this study

The aim of the study is to assess the feasibility of genomic and epigenetic analysis of rectal mucus to detect non-colorectal cancers of the aero- digestive tract using samples collected by the OriCol™ Sampling Device. The primary objective of the study is to assess whether significant changes in DNA mutation and methylation associated with Non-colorectal cancers of the Aero-digestive Tract (NCRCADT) can be detected in rectal mucus as shed cells and cell-free DNA (cfDNA) pass through the gut and theoretically can be collected from rectal mucus. Secondary objectives will assess the participant acceptability of the OriCol™ Sampling Device for Pancreatic Ductal Adenocarcinoma, Non-Small Cell Cancer of the Lung, Colorectal Cancer and Urological Cancer controls as well as contributing to a genomic library collating information about rectal mucus.

Condition
Non Small Cell Lung Cancer, Pancreatic Cancer, Bladder Cancer, Colorectal Cancer
Tested
Oricol Test
Sponsor
Origin Sciences

Who can join

Age
18 to 99 years
Sex
All sexes
Healthy volunteers
Not accepted

Inclusion 4

  • Minimum age: 18 years
  • Maximum age: 99 years
  • Study condition: Non Small Cell Lung Cancer, Pancreatic Cancer, Bladder Cancer, Colorectal Cancer
  • Aged 18 years or over Be able to give voluntary, written informed consent to participate in the study

Exclusion 1

  • Participants with symptoms that would make proctoscopic examination inappropriate, including acute anal fissure, symptomatic thrombosed haemorrhoids or obstructing anorectal lesions as determined by rectal examination Participants with a previous history of cancer Participants who have received previously radiotherapy, chemotherapy or immunotherapy for a malignancy.

Where

1 site, 1 recruiting

Royal Devon & Exeter NHS Foundation Trust

Exeter, United Kingdom

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.