Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
About this study
This 12-week controlled diet and weight intervention study seeks to define the molecular pathways that link excess body weight to the development of insulin resistance (IR). Blood, adipose and stool are sampled at three timepoints; baseline, peak weight (4 weeks) and post weight loss to monitor changes in cellular processes. Additionally, direct insulin sensitivity testing, and radiological measurement of visceral fat and intrahepatic fat content is measured at three timepoints to correlate clinical indices with cellular changes.
- Condition
- Diabetes Mellitus, Type 2, PreDiabetes, Insulin Resistance, Obesity, Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver, Diet Modification
- Tested
- Dietary Intervention Mediterranean Low Carbohydrate Diet, Dietary Intervention Standard Low Carbohydrate Diet, Dietary I...
- Sponsor
- Stanford University
Who can join
- Age
- 35 to 65 years
- Sex
- All sexes
- Healthy volunteers
- Accepted
Inclusion 7
- Minimum age: 35 years
- Maximum age: 65 years
- Study condition: Diabetes Mellitus, Type 2, PreDiabetes, Insulin Resistance, Obesity, Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver, Diet Modification
- Age 35-65
- BMI 25-35 kg/m2
- Stable body weight
- Nondiabetic
Exclusion 12
- Patients with;
- diabetes
- major organ disease
- history of liposuction or bariatric surgery
- active eating or psychiatric disorder
- pregnancy or lactation, heavy alcohol use
- recent change in weight (over the past 12 weeks)
- use of weight loss medication, statins, or oral steroids
- Clinical screening exclusions;
- hematocrit \< 33%
- fasting glucose \>/= 126 mg/dL
- blood pressure \>160/100 mmHg
Where
1 site, 1 recruiting
Stanford University
Stanford, California, United States
Contact
-
Ekrem M Ayhan, BS
908-619-5381 ayhane@stanford.edu
-
Dalia Perelman, MS, RD
Potential match only. Final eligibility is determined by the study team.