Preoperative Radiotherapy and Systemic Therapy Following Surgery in 'de Novo' Metastatic Breast Cancer
About this study
Locoregional (LRT) of the primary tumor in de-novo metastatic breast cancer (dnMBC) is no longer only a surgical challenge, but more the final decision of a multidisciplinary tumor board including medical oncologists, radiation oncologists and surgical oncologists. It is no longer only a question of locoregional control but rather a wider issue of improving overall survival (OS), due to the possible biological link between primary tumor and metastases. A multimodal approach, including LRT with curative intent should be considered for selected dnMBC patients, especially for the subset of bone-only metastatic ones.
- Condition
- Metastatic Breast Cancer
- Tested
- radiotherapy
- Sponsor
- Ankara Oncology Research and Training Hospital
Who can join
- Age
- 18 to 80 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
Inclusion 5
- Minimum age: 18 years
- Maximum age: 80 years
- Eligible sex: Female
- Study condition: Metastatic Breast Cancer
- Primary breast tumor amenable for complete surgical resection, patients in good physical condition for receiving protocol driven locoregional and systemic treatments and receiving radiotherapy.
Exclusion 2
- Primary tumor not amenable for complete resection; primary tumor with extended infection, bleeding, or necrosis; patients with poor physical condition which prevents the patient from receiving protocol driven locoregional and systemic treatment; synchronous primary cancer at the contralateral breast; clinically involved contralateral axillary nodes; patients not suitable for adequate follow-up, and failure to give informed consent.
- Pregnancy and lactation.
Where
1 site, 1 recruiting
Lutfi Dogan
Ankara, Turkey (Türkiye)
Contact
-
Lutfi Dogan, Prof
+905057134549 lutfidogan1@yahoo.com
Potential match only. Final eligibility is determined by the study team.