Prevention of Oxaliplatin-induced Nerve Damage in the Body's Extremities
About this study
The purpose of this study is to examine the effect of supplementary polyunsaturated fatty acids on nerve damage in the body's extremitites of patients treated with oxaliplatin containing chemotherapy after surgery for colorectal cancer.
- Condition
- Peripheral Neuropathy, Colorectal Cancer
- Tested
- Fish oil, Corn oil
- Sponsor
- Vejle Hospital
Who can join
- Age
- 18 years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 5
- Minimum age: 18 years
- Study condition: Peripheral Neuropathy, Colorectal Cancer
- Histopathologically verified adenocarcinoma of the colon or rectum and planned standard adjuvant treatment with capecitabine in combination with oxaliplatin.
- ECOG performance status 0-2 (measurement of a patient's function in terms of self-care, daily activity and physical ability.
- Written and orally informed informed consent
Exclusion 11
- Inability to speak, read, and understand Danish.
- Previous treatment with neurotoxic chemotherapy.
- Neurological (including neuropathy) or psychiatric disorders, diabetes or other significant medical conditions.
- Alcohol or drug abuse.
- Sensory disturbances in the feet
- Spinal stenosis.
- Vascular disease (Fontaine grade II or more).
- Known allergy to fish, fish oil or corn oil
- Fertile patients not willing to use effective methods of contraception during treatment or abstinence.
- Daily intake of oil supplements and not willing to stop during the trial period.
- Lack of consent to skin biopsy
Where
4 sites, 4 recruiting
Department of Oncology, AAUH
Aalborg, Denmark
Department of Oncology, AUH
Aarhus, Denmark
Department of Oncology
Sønderborg, Denmark
Department of Oncology, Vejle Hospital
Vejle, Denmark
Contact
-
Malene Nielsen, MD.
+45 26823726 Malene.Nielsen6@rsyd.dk
-
Karin Larsen
Potential match only. Final eligibility is determined by the study team.