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Recruiting Phase 2

The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction

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About this study

Caloric restriction (and RYGB) improves insulin action and lowers fasting glucose, glucagon and EGP, without changes in postprandial EGP and glucagon concentrations. Caloric restriction also improves hepatic steatosis and lowers fasting AA. These changes may represent restoration of glucagon's hepatic actions. This experiment will determine whether caloric restriction improves glucagon's actions on hepatic amino acid, carbohydrate and lipid metabolism in T2DM in comparison to a baseline experiment performed separately in people with T2DM.

Condition
Type2diabetes
Tested
Caloric Restriction, Hyperglycemic clamp
Sponsor
Adrian Vella

Who can join

Age
25 to 65 years
Sex
All sexes
Healthy volunteers
Not accepted

Inclusion 6

  • Minimum age: 25 years
  • Maximum age: 65 years
  • Study condition: Type2diabetes
  • We will recruit up to 20 weight-stable, subjects with type 2 diabetes
  • BMI ≥ 28 Kg/M2
  • Diabetes is managed by diet alone or a combination of oral agents

Exclusion 7

  • History of prior upper abdominal surgery e.g. gastric banding, pyloroplasty, vagotomy.
  • Active systemic illness or malignancy.
  • Symptomatic macrovascular or microvascular disease.
  • Contraindications to MRI (e.g. metal implants, claustrophobia).
  • Hematocrit \< 35%
  • TSH \< 0.4 or \> 5.5.
  • Consumption of \> 2 alcohol drinks per day or \> 14 per week or a positive AUDIT questionnaire.

Where

1 site, 1 recruiting

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.