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Cohort of Patients with Alzheimer's Disease and Their Families.

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About this study

This is the pilot phase of a longitudinal observational cohort study. The study includes family clusters comprised of a patient with Alzheimer's disease, an informal caregiver and at least one first-degree relative of the patient. The family clusters will be followed-up in expert memory centers and online in order to study risk and prognostic factors (including blood-based biomarkers) in the first-degree relatives and patients, respectively, as well as caregiver health, difficulties and needs. This pilot study is performed to assess the feasibility of conducting a larger-scale study.

Condition
Alzheimer Disease
Sponsor
University Hospital, Toulouse

Who can join

Age
18 years and older
Sex
All sexes
Healthy volunteers
Accepted

Inclusion 20

  • Minimum age: 18 years
  • Study condition: Alzheimer Disease
  • o Inclusion criteria:
  • AD patients:
  • Probable Alzheimer's disease (clinical and biological NINCDS-ADRDA 2011 criteria)
  • Mild-moderate AD (MMSE ≥15)
  • Sufficiently fluent in French in order to answer study questionnaires
  • Agrees to undergo medical examinations at baseline, 12 and 24 months, as outlined in the protocol
  • Affiliated to French social security
  • Written informed consent
  • Caregivers:
  • Caregiver (defined as assisting the patient in activities of daily living for at least 6 hours per week during the last 6 months) to an AD patient having agreed to participate in the study
  • Age ≥18 years.
  • Agrees to answer regular questionnaires about their own or the AD patient's health (during visits at study centres or via a secure internet website/postal questionnaires)
  • First-degree relatives:
  • First degree relative of an AD patient having agreed to participate in the study
  • Agrees to answer regular questionnaires about their own health (via a secure internet website or via postal questionnaires)
  • In order to be included in the study, a familial cluster must be comprised of 2 to 5 people, as follows:
  • Familial cluster of 2 people: 1 AD patient and 1 first-degree relative who also meets the caregiver inclusion criteria, OR
  • Familial cluster of 3 to 5 people: 1 AD patient, 1 caregiver (does not need to be a relative of the patient), 1 to 3 first-degree relatives of the patient

Exclusion 11

  • AD patients:
  • Other brain disorders
  • Autosomal dominant form of AD
  • Under legal protection measure (guardianship, curators, safeguard of justice…)
  • Institutionalized
  • Life expectancy \<2 years
  • Caregivers:
  • Diagnosed with a major neurocognitive disorder
  • First-degree relatives:
  • Related to a patient with an autosomal dominant form of dementia
  • Carrier of an autosomal dominant dementia mutation

Where

4 sites, 4 recruiting

Hôpitaux Universitaires de Marseille Timone

France, Marseille, France

Recruiting

CMRR Centre de Montpellier

Montpellier, France

Recruiting

CMRR Centre de Rouen

Rouen, France

Recruiting

CMRR - CRC Centre de Toulouse

Toulouse, France

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.