Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
About this study
There is limited information on what causes injury to the heart in individuals with Sickle Cell Disease (SCD). Researchers in this study want to see if decreased blood flow to the heart during stress could be causing the heart damage seen in SCD patients. They also want to test people who don't have SCD to see if their hearts react the same way under stress. Primary Objective * To estimate the coronary flow reserve (CFR) (also referred to as myocardial perfusion reserve), as measured by PET stress-rest myocardial perfusion imaging, in SCD patients with and without diastolic dysfunction, and healthy controls. Secondary Objectives * To investigate the relationship between decreased CFR (quantified with PET stress- rest myocardial perfusion imaging) and presence of abnormal diastolic parameters
- Condition
- Sickle Cell Disease
- Tested
- [13N]NH3, Lexiscan, Positron emission tomography
- Sponsor
- St. Jude Children's Research Hospital
Who can join
- Age
- 18 to 21 years
- Sex
- All sexes
- Healthy volunteers
- Accepted
Inclusion 7
- Minimum age: 18 years
- Maximum age: 21 years
- Study condition: Sickle Cell Disease
- 18 to 21 years of age
- Diagnosis of SCD of HbSS and HbSβ0thalassemia genotypes
- Three or more abnormal diastolic parameters (based on guidelines by American Society of echocardiography)
- Two or less abnormal diastolic parameters
Exclusion 20
- Recent hospitalization for vaso-occlusive pain crisis or acute chest syndrome in last 4 weeks
- Blood transfusion in the last 3 months
- Individuals with signs, symptoms or EKG findings of acute myocardial ischemia, infarction or unstable angina
- Individuals with history of VT/VF or SVT
- Previous cardiac surgery
- Known congenital heart disease (other than patent ductus arteriosus or Atrial septal defect)
- Stenotic valvular disease or left main coronary artery stenosis
- History of myo/pericarditis
- Left ventricle systolic dysfunction
- Cardiovascular instability/uncontrolled hypertension (h/o hypertensive urgency or emergency)
- History of sinus node dysfunction or high grade AV nodal block
- History of aborted sudden cardiac death or cardiac arrest
- Current seizure disorder on AED
- Pregnant/Breast-feeding
- Any medical or social reason, which, in the opinion of the principal investigators would make the participation of the subject ill-advised.
- Diagnosed with three or more abnormal diastolic parameters (based on guidelines by American Society of echocardiography)
- History of sinus node dysfunction or high-grade AV nodal block
- All genotypes of SCD
- Anemia of grade 2 or worse (per CTCAE v5.0) at study visit 1
- Pregnant/Breast- feeding
Where
1 site, 1 recruiting
St. Jude Children's Research Hospital
Memphis, Tennessee, United States
Contact
-
Parul Rai, MD
888-226-4343 referralinfo@stjude.org
Potential match only. Final eligibility is determined by the study team.