Shanghai At Risk for Alzheimer's Disease: a Cohort Study
About this study
The goal of this cohort study is to estimate the incidence of AD in the first-degree relatives of patients with AD. The main questions it aims to answer are: * cognitive changes of subjects at high risk of AD as ageing; * environmental and behavioral factors affecting AD incidence.
- Condition
- Alzheimer Disease, Dementia, Neurodegenerative Diseases, Cognitive Impairment, Neurocognitive Disorders
- Sponsor
- Ruijin Hospital
Who can join
- Age
- 50 years and older
- Sex
- All sexes
- Healthy volunteers
- Accepted
Inclusion 7
- Minimum age: 50 years
- Study condition: Alzheimer Disease, Dementia, Neurodegenerative Diseases, Cognitive Impairment, Neurocognitive Disorders
- the AD diagnostic criteria of probands meet the 2011 National Institute on Aging - Alzheimer's Association framework, and participants are the first-degree relatives (including parents, children and siblings of the same father and mother) of the proband;
- not patients with dementia;
- ≥ 50 years, males and females;
- subjects have lived in Shanghai for more than 1 year and have no plan to move out of Shanghai within 5 years;
- subjects are able to complete investigation, physical examination, imaging examination and biological specimen collection.
Exclusion 5
- Individuals will be excluded if they have:
- other diseases which could cause cognitive decline, e.g. cerebrovascular diseases, Creutzfeldt-Jakob disease and Parkinsons disease;
- history of psychological disorders (according to Diagnostic and Statistical Manual of Mental Disorders, 5th Edition);
- uncorrectable visual or auditory impairment that hampers the completion of related examination.
- pre-menopausal women will also be excluded.
Where
1 site, 1 recruiting
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
Contact
-
Gang Wang, MD, PhD
086-021-64370045 wg11424@rjh.com.cn
Potential match only. Final eligibility is determined by the study team.