Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)
About this study
To collect Tau PET/CT imaging in older adults diagnosed with Mild Cognitive Impairment (MCI) or Alzheimer's Disease (AD) in the Mismatch Prospective Cohort Study (MPC-Tau) study to determine relationship to clinical, cognitive, and other biomarker data. Findings from this study will likely provide insight into the phenotypic variability of Alzheimer's Disease and other related pathologies.
- Condition
- Alzheimer's Disease
- Tested
- AV-1451
- Sponsor
- University of Pennsylvania
Who can join
- Age
- 18 to 120 years
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 6
- Minimum age: 18 years
- Maximum age: 120 years
- Study condition: Alzheimer's Disease
- Enrolled in MPC study (Protocol 850160 at UPenn; Protocol 2022P002447 at MGH).
- Reliable study partner to accompany participant to the PET/CT scan
- A brain MRI must be performed within 6 months prior to their study AV-1451 TAU PET/CT scan date and be deemed of adequate quality that the scan may be used for study analysis, including 3T high-resolution imaging of medial temporal lobe structures.
Exclusion 5
- Have any medical or psychiatric conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study.
- Have evidence of structural abnormalities such as major stroke or mass on MRI that is likely to interfere with analysis of the PET/CT scan.
- Inability to tolerate or contraindication to imaging procedures in the opinion of an investigator or treating physician.
- Have a history of significant ongoing alcohol or substance abuse based on self- report.
- Female participants of child-bearing age will not be able to participate in this study, determined by self-report.
Where
2 sites, 2 recruiting
Massachusetts General Hospital
Boston, Massachusetts, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Contact
-
Jacqueline Lane
610-299-1243 Jacqueline.Lane@pennmedicine.upenn.edu
Potential match only. Final eligibility is determined by the study team.