Type 2 Diabetes, Obesity and Cortisol Excess
About this study
The present observational cross-sectional study is aimed to assess: the hidden hypercortisolism (HidHyCo) prevalence in a sample of Type 2 diabetes (T2D) patients and the clinical characteristics more frequently associated with the HidHyCo presence and the HidHyCo prevalence in an adequate sample of obese patients without T2D and the clinical characteristics more frequently associated with the HidHyCo presence.
- Condition
- Diabetes Mellitus, Type 2, Obesity, Cortisol; Hypersecretion
- Tested
- 1mg DST
- Sponsor
- Istituto Auxologico Italiano
Who can join
- Age
- 18 to 75 years
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 4
- Minimum age: 18 years
- Maximum age: 75 years
- Study condition: Diabetes Mellitus, Type 2, Obesity, Cortisol; Hypersecretion
- patients with T2D and Obesity
Exclusion 7
- pregnancy/breast feeding,
- sleep apnea,
- prepuberal onset of hypertension, hormonal hypersecreting adrenal mass,
- symptoms of hypercortisolism;
- already known secondary hypertension;
- conditions associated with increased hypothalamic-pituitary-adrenal (HPA) axis activity, -severe autoimmune/rheumatologic and hematologic diseases, alcoholism, kidney disease (glomerular filtration rate \<60)
- drugs influencing the HPA axis activity. For inclusion in Group 2 the presence of T2D will be an exclusion criteria
Where
5 sites, 5 recruiting
Istituto Auxologico Italiano
Milan, Italy
Niguarda Hospital
Milan, Italy
Campus Bio-Medico University
Roma, Italy
University of Siena
Siena, Italy
Azienda Ospedaliero Universitaria, Santa Maria della Misericordia di Udine
Udine, Italy
Contact
-
Valentina Morelli, PhD
02619112547 v.morelli@auxologico.it
Potential match only. Final eligibility is determined by the study team.