Skip to content
TrialMatch
Sign up
Recruiting

Prevalence, Incidence and Risk Signature of Chronic Kidney Disease in Sub-Saharan Africa

Create a profile to match View the full record on ClinicalTrials.gov

About this study

Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity and mortality. The prevalence of CKD is increasing worldwide and is assumed to also dramatically increase in Sub-Saharan Africa (SSA). Key shortcomings of available data on CKD in SSA are as follows: (i) Available data are based on single measurements and, therefore, cannot distinguish between harmless transient deterioration in kidney function and chronic kidney damage; (ii) Accurate information regarding renal protein loss, an important and early marker of kidney disease, is lacking; (iii) Cardiovascular risk factors for CKD, such as obesity, hypertension and diabetes, are often not searched for. Likewise non-classic potential risk factors, such as endemic infectious diseases, socioeconomic status and lifestyle have not been consistently recorded; (iv) Information to interrogate linked interaction over time between risk factors and development of CKD is unavailable. With this project, situated in a region representative of semi-rural SSA, we aim to fill this knowledge gap and (i) establish guideline conform prevalence data of CKD and its major cardiovascular risk factors, as well as (ii) prospectively define the incidence of cardiovascular- and non-classic risk factors of CKD. The data from (i) and (ii) is used to develop predictive models. A prospective cohort of 1200 individuals in a primary care facility will serve as study population. The population is representing a society in transition from rural to more urban lifestyle. In the pilot study, participants will be followed for one years and undergo the clinical and biomedical testing required to capture CKD and its classic and non-classic risk factors over time.

Condition
Chronic Kidney Diseases, Type 2 Diabetes Mellitus, Arterial Hypertension, Obesity, Cardiovascular Diseases, HIV Infections, Anemia, Underweight, Infections, Albuminuria, Dyslipidemias
Sponsor
Swiss Tropical & Public Health Institute

Who can join

Age
18 to 99 years
Sex
All sexes
Healthy volunteers
Not accepted

Inclusion 4

  • Minimum age: 18 years
  • Maximum age: 99 years
  • Study condition: Chronic Kidney Diseases, Type 2 Diabetes Mellitus, Arterial Hypertension, Obesity, Cardiovascular Diseases, HIV Infections, Anemia, Underweight, Infections, Albuminuria, Dyslipidemias
  • all adult patients (≥18 years) attending the outpatients department of the Bagamoyo district hospital (BDH) or the associated Fukayosi and Yombo dispensary

Exclusion 4

  • \<18 years of age
  • not living in the BDH catchment area
  • not of African decent
  • not willing to come back for follow-up visits

Where

1 site, 1 recruiting

Bagamoyo District Hospital

Bagamoyo, Coast Region, Tanzania

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.