A Multi-domain Lifestyle Intervention Among Aged Community-residents in Zhejiang, China
About this study
A study conducted in Finland discovered that a multidomain intervention, consisting of physical activity, nutritional guidance, cognitive training, social activities, and management of vascular risk factors, effectively decelerated cognitive decline in healthy older adults who were at an increased risk of cognitive decline. The HERITAGE study is a 2-year clustered randomized controlled trial (clustered-RCT) that explores the efficacy of a multidomain intervention among 1200 elderly residents with a higher risk of cognitive decline and dementia in Zhejiang Province, China
- Condition
- Cognitive Impairment, Alzheimer Disease, Vascular Cognitive Impairment, Dement, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases, Neurocognitive Disorders, Mental Disorder, Cognition Disorder
- Tested
- Structured Multi-domain Intervention, Self-Guided Intervention
- Sponsor
- Zhejiang University
Who can join
- Age
- 60 to 80 years
- Sex
- All sexes
- Healthy volunteers
- Accepted
Inclusion 7
- Minimum age: 60 years
- Maximum age: 80 years
- Study condition: Cognitive Impairment, Alzheimer Disease, Vascular Cognitive Impairment, Dement, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases, Neurocognitive Disorders, Mental Disorder, Cognition Disorder
- At risk of cognitive decline: cognitive performance at the mean level or slightly lower than expected for age with no dementia (AD8\>=3 and/or 5-min MoCA \>, \< 11)
- Free of physical disabilities that preclude participation in the study
- Willing to complete all study-related activities for 24 months
- Willing to be randomized to either lifestyle intervention group
Exclusion 6
- Diagnosed dementia patients
- Diagnosed major depression or other neuropsychological diseases
- Malignant diseases
- Symptomatic cardiovascular disease
- Revascularization within one year
- Severe loss of vision, hearing or communicative ability
Where
1 site, 1 recruiting
School of Public Health and The Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, China
Hangzhou, Zhejiang, China
Contact
-
Xin Xu, PhD
+8613575760802 xuxinsummer@zju.edu.cn
-
Changzheng Yuan, PhD
Potential match only. Final eligibility is determined by the study team.