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Shanghai Non-pharmacological Intervention for Mild Cognitive Impairment and Mild Alzheimer's Disease

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About this study

This study is a multicentre, randomized, double-blind, controlled trial that aims to investigate the efficacy of multi-domain life-style intervention including low inflammatory-index diet, exercise, and cognitive training in patients with mild cognitive impairment and mild Alzheimer's disease.

Condition
Mild Cognitive Impairment, Mild Dementia
Tested
Diet intervention, Exercise, Cognitive training
Sponsor
Ruijin Hospital

Who can join

Age
60 to 90 years
Sex
All sexes
Healthy volunteers
Not accepted

Inclusion 9

  • Minimum age: 60 years
  • Maximum age: 90 years
  • Study condition: Mild Cognitive Impairment, Mild Dementia
  • Aged 60-90 years
  • In accordance with the diagnostic criteria for "mild cognitive impairment due to Alzheimer's disease" or "mild Alzheimer's disease" from the National Institutes of Health National Institute on Aging-Alzheimer's Association (NIA-AA) (2011)
  • The Hamilton depression rating scale/17 edition (HAMD) total scoreā‰¤10
  • Neurological examination: no obvious signs
  • Education: primary school (grade 6) or above and capacity to complete tests for cognitive ability
  • Capacity to give consent

Exclusion 10

  • Other causes of cognitive decline: cerebrovascular disease, central nervous system infection, Creutzfeldt-Jakob disease, Huntington's and Parkinson's disease, Creutzfeldt-Jakob disease, traumatic brain dementia, other physical and chemical factors (such as drugs, alcohol, CO), systemic disease (hepatic encephalopathy, pulmonary encephalopathy, etc.), intracranial occupation (a subdural hematoma, brain tumor), the endocrine system disease (thyroid disease, parathyroid disease), and vitamins deficiency or any other causes of dementia
  • The history of nervous system diseases, including stroke, optic myelitis, Parkinson's disease, epilepsy, etc
  • Psychiatric patients, including schizophrenia or other mental illnesses, bipolar disorder, major depression, or delirium
  • There are unstable or serious heart, lung, liver, kidney, endocrine, and hematopoietic system diseases, or Poor prognosis because of malignant diseases such as tumors.
  • Vision or hearing problems that lead to poor performance on cognitive tests
  • Two years history of severe alcoholism, and drug abuse
  • Participants who participated in any other trial 30 days prior to their screening visit
  • Contraindication of MRI scanning
  • Special requirements for diet, e.g., allergy to common food or on a special diet due to medical needs
  • Participants who cannot be followed for at least 6 months (due to a health situation or migration)

Where

1 site, 1 recruiting

Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine

Shanghai, Shanghai Municipality, China

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.