Probiotics in Mild Alzheimer's Disease
About this study
The main objective is to investigate whether administration of probiotics to patients with mild Alzheimer's Disease (AD) reduces neuroinflammation, improves cognitive function and modifies neurophysiological measures, compared to a patient group that receives placebo (no active probiotics).
- Condition
- Neurodegenerative Diseases, Cognition Disorders in Old Age
- Tested
- Probiotic Blend Capsule
- Sponsor
- University of Nicosia
Who can join
- Age
- 65 to 85 years
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 6
- Minimum age: 65 years
- Maximum age: 85 years
- Study condition: Neurodegenerative Diseases, Cognition Disorders in Old Age
- Adults ≥65 years, able to give consent
- Mini-Mental State Examination (MMSE) scores 19-23 (mild AD)
- approximately equal male:female ratio
Exclusion 15
- Inability to give consent
- other neurological disease
- relevant psychiatric disorders (e.g. major depression)
- gastrointestinal/metabolic conditions
- history of alcohol/substance dependence
- use of systemic antibiotics in the previous 6 months
- corticosteroid use
- immune stimulating medications
- immunosuppressive agents
- probiotics consumption in the previous 6 months.
- immunosuppression
- structural heart disease
- neutropenia
- radiation
- active intestinal disease
Where
1 site, 1 recruiting
The Cyprus Institute of Neurology and Genetics
Nicosia, Cyprus
Contact
-
Nicoletta Nicolaou
+35722471903 nicolaou.nic@unic.ac.cy
Potential match only. Final eligibility is determined by the study team.