Uganda Sickle Surveillance Study (US-3)
About this study
It is estimated that over 250,000 babies are born with sickle cell disease (SCD) annually in sub-Saharan Africa, and only 10% - 50% of them survive beyond five years of age. Data describing the magnitude of the sickle cell problem are lacking in most African countries. The available data on prevalence were mainly from older studies and small numbers of hospitalized patients. In Uganda, approximately 25,000 children are born with SCD but 70-80% die before their 5th birthday. Lehmann and Raper found 'sicklaemia' prevalence of 0.8% and 45% in the Sebei and Bambaa ethnic groups, respectively. A recent study found a SCT and SCD prevalence of 3% - 19% and 0% - 3%, respectively but this study addressed only 5 of Uganda's 111 districts and used a small convenience sample of children aged 6 - 60 months. The objective of this study is to determine the prevalence and map out the burden of SCT and SCD in Uganda.
- Condition
- Sickle Cell Disease
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Who can join
- Age
- Up to 1 years
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 3
- Maximum age: 1 years
- Study condition: Sickle Cell Disease
- Up to 1,000,000 samples may be collected during 2015 - 2030 following primary analysis based on surveillance findings.
Exclusion 1
- Repeat samples on the same individuals during the study period will be excluded.
Where
4 sites, 4 recruiting
Makerere University
Kampala, Uganda
Minister of Health
Kampala, Uganda
National Coordinator EID Program
Kampala, Uganda
Sickle Cell Clinic Department of Pediatrics & Child Health Mulago Hospital
Kampala, Uganda
Contact
-
Teresa Latham, MA
5138037922 teresa.latham@cchmc.org
-
Wendi Long
Potential match only. Final eligibility is determined by the study team.