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INSIDE: Identification of Genomic Screening Pathways in Cancer Patients With DNA Repair Alterations

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About this study

400 patients will be enrolled and divided into 3 cohorts: Cohort A: patients with high risk localized prostate cancer (PC) defined as \>cT3 or PSA \> 20 ng/mL or presence of ECE or SVI at mpMRI; Cohort B: patients with de novo metastatic hormone sensitive prostate cancer (mHSPC); Cohort C: patients with metastatic castration resistant prostate cancer (mCRPC) progressing on a standard treatment.

Condition
Prostate Cancer
Sponsor
Fondazione del Piemonte per l'Oncologia

Who can join

Age
18 years and older
Sex
Male only
Healthy volunteers
Not accepted

Inclusion 10

  • Minimum age: 18 years
  • Eligible sex: Male
  • Study condition: Prostate Cancer
  • Age \> 18 years
  • Diagnosis of prostate cancer as indicated below:
  • Cohort A: patients with high risk localized prostate cancer (defined as \>cT3 or PSA \> 20 ng/mL or presence of ECE or SVIat mpMRI), with tissue available from diagnostic biopsy/ prostatectomy undergoing or who underwent curative treatment (prostatectomy/ radical radiotherapy) but have not started a FU pathway.
  • Cohort B: patients with de novo metastatic hormone sensitive prostate cancer (mHSPC) with tissue available from diagnostic biopsy of the primary and when possiblepossible, from a metastatic site. Patients must either have not started a standard treatment or have started for not longer than 3 months.
  • Cohort C: patients with metastatic castration resistant prostate cancer tissue (mCRPC) progressing on a standard treatment with available from biopsy of a metastatic site, and when possiblepossible, from the primary.
  • Ability to understand and consent to informed consent;
  • Patient must be compliant with receiving a biopsy of the metastatic site (cohort C) and with FU assessments schedule

Exclusion 1

  • Patients not willing to comply with study's procedures or fulfilling the inclusion criteria.

Where

2 sites, 2 recruiting

Fondazione del Piemonte per l'Oncologia-IRCCS Candiolo

Candiolo, Turin, Italy

Recruiting

AOU San Luigi Gonzaga

Orbassano, Turin, Italy

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.