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The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)

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About this study

The goal of this clinical trial is to learn about the effects of social isolation and social interaction on the risk of dementia progression and brain function in SCD 1. To explore the association between social isolation and lonely SCD populations and the occurrence and progression of MCI and AD through cross-sectional studies, cohort studies and randomized controlled trials of SCD; 2. To clarify the correlation between different carrier states, resting brain function connectivity characteristics, and dual-task walking ability of APOEε4 allele and the progression of SCD to MCI and AD during the cognitive progress of people with SCD affected by social isolation; 3. Establish a predictive model of cognitive decline from SCD to MCI and AD, and apply it to the SCD population to carry out individualized interventions; 4. Confirm the protective effect of social interaction on cognitive level and brain function in SCD patients.

Condition
Social Isolation, SCD, Subjective Cognitive Decline, MCI, Mild Cognitive Impairment, AD, Alzheimer Disease
Tested
social isolation
Sponsor
The First Affiliated Hospital with Nanjing Medical University

Who can join

Age
45 to 85 years
Sex
All sexes
Healthy volunteers
Accepted

Inclusion 6

  • Minimum age: 45 years
  • Maximum age: 85 years
  • Study condition: Social Isolation, SCD, Subjective Cognitive Decline, MCI, Mild Cognitive Impairment, AD, Alzheimer Disease
  • Self-perceived continuous cognitive decline compared with the previous normal state, and is not related to acute events;
  • After adjustment for age, gender, and years of education, the standard cognitive test is normal, or the diagnostic criteria for MCI are not met;
  • Selected candidates can sign the informed consent form themselves.

Exclusion 8

  • (a) Aged under 45 years or older than 85 years;
  • (b) Vascular dementia or other central nervous system diseases;
  • (c) Hachinski Ischemic Scale score \> 4 points;
  • Unable to complete neuropsychological tests (e.g., blindness, deafness, severe language impairment);
  • (e) Drug abuse or alcohol dependency within the last 6 months;
  • (f) Current participation in other cognition studies;
  • (g) Severe diabetes mellitus, or severe cardiovascular disease, cerebrovascular disease, liver diseases, kidney diseases, psychiatric disorders;
  • (h) Contraindications to imaging techniques: claustrophobia, metallic implants (e.g., intracranial metal clips), electronic devices (e.g., cardiac pacemakers)

Where

1 site, 1 recruiting

The First Affiliated Hospital of Nanjing Medical University

Nanjing, China, Jiangsu, China

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.