Fiber Supplementation in Heart Failure With Preserved Ejection Fraction (HFpEF)
About this study
The study team is studying how increasing dietary fiber, specifically through adding potato starch to participant's diet, may impact the species of bacteria in participant's gut microbiome. The study team also wants to understand if adding potato starch to participant's diet helps these bacteria make more short chain fatty acids, a byproduct the team thinks may benefit participant's health.
- Condition
- Type2diabetes, Heart Failure With Preserved Ejection Fraction
- Tested
- Potato Starch
- Sponsor
- University of Michigan
Who can join
- Age
- 18 years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 5
- Minimum age: 18 years
- Study condition: Type2diabetes, Heart Failure With Preserved Ejection Fraction
- A confirmed clinical diagnosis of stable HFpEF on maximally tolerated Heart Failure (HF) medical regimen (without changes in dosage in the prior month)
- Left ventricular ejection fraction of \>50% documented in the prior 12 months
- A confirmed clinical diagnosis of Type II diabetes (T2DM) with glycated hemoglobin \<10% without changes in medical regimen in the past month.
Exclusion 8
- Current usage of pre- or probiotic usage
- Antibiotic usage in the past 6 months
- Current participation in another interventional clinical trial
- History of potato allergy or potato starch allergy, inflammatory bowel syndrome, inflammatory bowel disease, bowel resection, Roux-en-Y gastric bypass surgery, celiac disease, Crohn's disease, or colorectal cancer
- Hypoglycemic episode with blood glucose 70 milligrams per deciliter (mg/dL) within the last month
- Stage IV-V chronic kidney disease
- Pregnancy (self-reported)
- Comorbidity limiting survival to \< 12 months
Where
1 site, 1 recruiting
University of Michigan
Ann Arbor, Michigan, United States
Contact
-
Hayley Billingsley, PhD
734-726-0308 hbilings@med.umich.edu
Potential match only. Final eligibility is determined by the study team.