Recruiting
Phase 3
Liraglutide in Preventing Delirium in Diabetic Elderly After Cardiac Surgery
About this study
This study aims to clarify the preventive effect of perioperative liraglutide application on postoperative delirium in elderly patients with Type 2 diabetes undergoing cardiac surgery.
- Condition
- Delirium, Postoperative
- Tested
- Liraglutide injection, Placebo injection
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Who can join
- Age
- 60 years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 5
- Minimum age: 60 years
- Study condition: Delirium, Postoperative
- Age ≥ 60 years
- Type 2 diabetes
- Patients undergoing elective cardiac surgery
Exclusion 14
- History of neurological or psychiatric disorders, such as schizophrenia, epilepsy, Parkinson's disease, severe dementia, etc
- Patients with communication difficulties, such as severe visual, auditory, or speech impairments
- History of central nervous system damage or surgery
- Cardiac function NYHA Class IV
- Severe liver dysfunction (Child-Pugh Class C)
- Severe renal failure requiring renal replacement therapy
- History of pancreatitis
- Type 1 diabetes
- Patients whose blood sugar is difficult to control within 4-8 mmol/L during the screening period
- Patients with medullary thyroid carcinoma or a family history of it
- Pregnant or breastfeeding women
- Intolerance or allergy to liraglutide
- Previous use of GLP-1A and SGLT2i
- Patients who refuse to sign the informed consent
Where
1 site, 1 recruiting
Wenxue liu
Nanjing, Jiangsu, China
Contact
-
Wenxue Liu, PhD，MD
15751866806 diligent_hi@163.com
Potential match only. Final eligibility is determined by the study team.