Investigating Neurocognitive Disorders Epidemiology
About this study
This is a prospective cohort study with the main purpose of predicting progression neurocognitive disorders in Thai population. The main predictor variables to be evaluated are plasma phosphorylated tau (p-tau) level and cognitive test scores, which will be combined using statistical/computational modeling. Additionally, it seeks to evaluate biomarkers for diagnosing disease pathologies, understand their correlation with clinical outcomes, and explore the socioeconomic impact of neurocognitive disorders. The study invites both participants for biospecimen collection, structured interviews, and cognitive examinations and schedules follow-up visits annually or biennially.
- Condition
- Dementia, Cognitive Decline, Alzheimer Disease
- Tested
- Plasma tau phosphorylated at Thr217, Neurocognitive examination
- Sponsor
- King Chulalongkorn Memorial Hospital
Who can join
- Age
- 35 years and older
- Sex
- All sexes
- Healthy volunteers
- Accepted
Inclusion 10
- Minimum age: 35 years
- Study condition: Dementia, Cognitive Decline, Alzheimer Disease
- Cognitively Healthy Individuals
- Demonstrate normal cognitive function within the expected range on objective cognitive tests.
- Proficient in speaking and understanding Thai without the need for a translator to participate.
- Display impaired/abnormal performance on objective cognitive tests.
- Does not meet criteria for dementia per NIA-AA (or major neurocognitive disorder per DSM-5).
- Meets criteria for dementia per NIA-AA (or major neurocognitive disorder per DSM-5), including dementia due to Alzheimer's disease or other causes.
- Begins to experience symptoms, identified by the physician as a part of dementia continuum, occurring after the age of 65.
- Begins to experience symptoms, identified by the physician as a part of dementia continuum, occurring before the age of 65.
Exclusion 5
- Significant neurological or uncontrolled psychiatric illness.
- Significant unstable systemic condition or end-stage organ failure that affects study participation.
- Mild Cognitive Impairment
- Late Onset Dementia
- Early Onset Dementia
Where
1 site, 1 recruiting
King Chulalongkorn Memorial Hospital
Pathum Wan, Bangkok, Thailand
Contact
-
Poosanu Thanapornsangsuth, M.D.
+66 (0)2 2564000 poosanu.t@chula.ac.th
-
Thanakit Pongpitakmetha, M.D.
Potential match only. Final eligibility is determined by the study team.