Recruiting Phase 3

Haplo-cord HCT vs. Haplo-HCT for T-ALL Patients

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About this study

The goal of this clinical trial is to learn if haploidentical hematopoietic cell transplantation combined with an unrelated cord blood unit (haplo-cord HCT) works to treat acute T cell lymphoblastic leukemia (T-ALL). It will also learn about the safety of the transplantation. The main questions it aims to answer are: Dose co-infusion of cord blood in haploidentical hematopoietic cell transplantation (haplo-HCT) lower the rate of relapse? What medical problems do participants have when having haplo-cord HCT? Researchers will compare haplo-cord HCT to haplo-HCT to see if haplo-cord HCT works to treat T-ALL. Participants will be infused an unrelated cord blood unit at the same day of haploidentical graft infusion.

Condition: Acute T Cell Lymphoblastic Leukemia, Haploidentical Hematopoietic Stem Cell Transplantation, Cord Blood
Tested: Haplo-cord HCT, Haplo-HCT
Sponsor: The First Affiliated Hospital of Soochow University

Who can join

Age: Not specified
Sex: All sexes
Healthy volunteers: Not accepted

Inclusion 6

Study condition: Acute T Cell Lymphoblastic Leukemia, Haploidentical Hematopoietic Stem Cell Transplantation, Cord Blood
Patients with acute T cell lymphoblastic leukemia
With available minimal residual disease parameters assessed by flow cytometry and/or quantitative polymerase chain reaction
Willing to undergo haploidentical hematopoietic cell transplantation and having a suitable haploidentical donor
With Eastern Cooperative Oncology Group (ECOG) performance status of 0-3
Signing an informed consent form, having the ability to comply with study and follow-up procedures

Exclusion 7

With other malignancies
Failing to acquire a suitable unrelated cord blood unit
With a previous history of autologous hematopoietic cell transplantation, allogeneic hematopoietic cell transplantation or chimeric antigen receptor T cell therapy
With uncontrolled infection intolerant to haploidentical hematopoietic cell transplantation
With severe organ dysfunction
In pregnancy or lactation period
With any conditions not suitable for the trial (investigators' decision)

Where

1 site, 1 recruiting

The First Affiliated Hospital of Soochow University

Suzhou, Jiangsu, China

Recruiting

Contact

Yang XU

86+051267781850 xuyang1020@126.com

Potential match only. Final eligibility is determined by the study team.