Physiology and Pathologies Linked to Human Splenic Function : Direct and Ex-vivo Perfusion Explorations
About this study
Human splenic physiology remains poorly understood due to lack of functional exploration. However, through its ability to recognize alterations or modifications in circulating cells and to trigger an innate and adaptive response in response to these anomalies, the spleen plays a central role in several diseases affecting blood cells, directly or indirectly. The analysis of the splenic clearance of abnormal cells during ex-vivo perfusions made it possible to clarify the pathogenesis of malaria and the role of the spleen in the adaptive immune response. The study's investigative team wishes to extend these explorations to other human diseases in which the spleen is involved, and to evaluate the preventive or curative potential of substances that can modify the perception of blood cells by the spleen (e.g. monoclonal antibodies directed against circulating cells, among other options).
- Condition
- Splenectomy
- Tested
- Spleen, blood and plasma collection
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Who can join
- Age
- 18 years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 4
- Minimum age: 18 years
- Study condition: Splenectomy
- Adult patients
- Patient requiring left splenopancreectomy or planned splenectomy regardless of the method or indication
Exclusion 1
- \- The patient notified his doctor of his refusal to recover his spleen and blood volume
Where
5 sites, 4 recruiting
Hôpital Beaujon
Clichy, France
Hôpital Saint Antoine
Paris, France
Hôpital Pitié Salpêtrière
Paris, France
Hôpital Necker-Enfants Malades
Paris, France
Institut Pasteur
Paris, France
Contact
-
Pierre Buffet, MD, PhD
-
Hélène Morel
1 71 49 63 46 helene.morel@aphp.fr
Potential match only. Final eligibility is determined by the study team.