Insulin and Insulin Pulses During Fasting
About this study
Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes. However, little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state. The proposed experiment is part of a series of experiments designed to establish how glucagon and insulin interact with their receptors to control fasting glucose in health and in prediabetes.
- Condition
- PreDiabetes
- Tested
- Intralipid and heparin, Saline
- Sponsor
- Mayo Clinic
Who can join
- Age
- 25 to 65 years
- Sex
- All sexes
- Healthy volunteers
- Accepted
Inclusion 4
- Minimum age: 25 years
- Maximum age: 65 years
- Study condition: PreDiabetes
- people with normal or impaired fasting glucose and normal or impaired glucose tolerance
Exclusion 8
- HbA1c \> 6.5%
- BMI ≥ 35 Kg/M2
- Use of any glucose-lowering agents including metformin or sulfonylureas.
- For female subjects: positive pregnancy test at the time of enrollment or study
- History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
- Active systemic illness or malignancy.
- Symptomatic macrovascular or microvascular disease.
- Hematocrit \< 35%
Where
1 site, 1 recruiting
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Contact
-
Kim Osmundson, CCRP
507-255-0907 Osmundson.Kimberly@mayo.edu
-
Jeanette Laugen
507-255-8110 Laugen.Jeanette@mayo.edu
Potential match only. Final eligibility is determined by the study team.