Recruiting Phase 2

Ga-68-CXCR4 PET/CT in Indolent B-cell Lymphoma

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About this study

This study explores the efficacy of Ga-68-PentixaFor PET/CT in detecting, assessing treatment response, and monitoring the risk of aggressiveness in indolent B-cell lymphoma. The background introduces CXCR4 and discusses its role in cancer research. Currently, FDG-PET is the primary imaging tool for lymphoma staging, but it lacks diagnostic accuracy for low-grade lymphomas. Ga-68-PentixaFor PET demonstrates promising detection capabilities across various lymphomas, suggesting its potential as a superior imaging modality for low-grade lymphomas.

Condition: Indolent B-Cell Non-Hodgkin Lymphoma
Tested: Ga-68-CXCR4
Sponsor: Koo Foundation Sun Yat-Sen Cancer Center

Who can join

Age: 20 to 100 years
Sex: All sexes
Healthy volunteers: Not accepted

Inclusion 9

Minimum age: 20 years
Maximum age: 100 years
Study condition: Indolent B-Cell Non-Hodgkin Lymphoma
The pathological diagnosis is slow-growing lymphoma, such as: marginal-zone B-cell lymphoma, Waldenstrom macroglobulinemia lymphocytic lymphoma, CLL/SLL, mantle cell lymphoma.
Have undergone or planned to undergo FDG PET scan for indications including initial staging, therapeutic response evaluation, or follow-up examinations within 3 to 6 months in the clinical observation group.
Able to lie flat for at least 30 minutes.
Signing the subject consent form.
ECOG grade 0-2.
The timing of F-18-FDG usage in this trial follows the "Lymphoma Treatment Principles" of our institution.

Exclusion 7

Pregnant woman
Severe renal impairment (eGRF\< 30ml/min)
Known or suspected allergy to radiopharmaceuticals
Concurrent or previous diagnosis of malignancies other than lymphoma
Inability to undergo the necessary PET scan procedure
Refusal or unwillingness to sign the informed consent form
Severe medical conditions (severe disabilities, mental disorders)

Where

1 site, 1 recruiting

Koo Foundation Sun Yat-Sen Cancer Center

Taipei, Beitou, Taiwan

Recruiting

Contact

Yu Yi Huang, MD

+886 28970011 yuyi@kfsyscc.org
Cheng Ling Yang, B.Rad.

+886 28970011 androgyny@kfsyscc.org

Potential match only. Final eligibility is determined by the study team.