Peripheral Arterial Tonometry and Neurocognition in Sickle C...

About this study

This study will examine sleep disordered breathing and sleep quality in participants (ages 12-25) diagnosed with sickle cell disease of any genotype. We will utilize remote peripheral arterial tonometry (PAT) and questionnaires to evaluate difficulties with sleep. PAT assessments will occur remotely in the homes of participants. Neurocognitive, behavioral, and neuroimaging evaluations will occur on the same day as a routine clinic visit. Primary Objective: Evaluate the relationship between nocturnal oxyhemoglobin saturation (SpO2) and neurocognitive functioning (working memory and verbal comprehension) in individuals (ages 12-25) diagnosed with sickle cell disease controlling for age, genotype, and social vulnerability. Secondary Objective: Assess differences in white matter integrity, silent cerebral infarcts, neuroinflammation, and functional connectivity among individuals (ages 12-25) diagnosed with sickle cell disease with and without sleep disordered breathing after controlling for age. Assess differences in self- and caregiver-reported mood and pain severity among individuals (ages 12-25) diagnosed with sickle cell disease with and without sleep disordered breathing after controlling for age. Exploratory Objectives: Explore the relationship between nocturnal oxyhemoglobin saturation (SpO2) and neurocognitive functioning (attention, processing speed, verbal memory, visual memory, motor dexterity) in individuals (ages 12-25) diagnosed with sickle cell disease controlling for age, genotype, and social vulnerability. Assess the feasibility of an optical imaging tool (Speckle Contrast Optical Spectroscopy - Open-Motion 3.0) to measure cerebral blood flow and blood volume in patients diagnosed with sickle cell disease (ages 12-25). Assess the concordance between measurement of cerebral blood flow and volume using speckle contrast optical spectroscopy and arterial spin labeling brain MRI.

Condition: Sickle Cell Disease
Sponsor: St. Jude Children's Research Hospital

Who can join

Age: 12 to 25 years
Sex: All sexes
Healthy volunteers: Not stated

Inclusion 8

Minimum age: 12 years
Maximum age: 25 years
Study condition: Sickle Cell Disease
Diagnosed with sickle cell disease of any genotype
Participant in the Sickle Cell Clinical Research and Intervention Program
Between 12-25 years of age at the time of enrollment
English is the primary language
Access to an electronic device with WiFi

Exclusion 6

History of an intellectual disability
History of a traumatic brain injury or seizure disorder
History of a stroke
Undergoing potential curative treatment for SCD (stem cell transplant or gene therapy)
Currently prescribed an intervention for a sleep disorder
Inability or unwillingness of research participant or legal guardian/representative to give written informed consent.

Where

1 site, 1 recruiting

St. Jude Children's Research Hospital

Memphis, Tennessee, United States

Recruiting

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