Study on Multimodal Imaging and Molecular Imaging Techniques in Degenerative Dementia
About this study
This project is a multicenter observational study that establishes a longitudinal cohort of patients with Alzheimer's disease and other dementias based on neuroimaging, molecular imaging, biological and digital markers to explore new solutions such as dementia disease mechanism, diagnosis, condition evaluation, and prognosis assessment.
- Condition
- Alzheimer Disease, Image
- Sponsor
- Ruijin Hospital
Who can join
- Age
- 50 to 85 years
- Sex
- All sexes
- Healthy volunteers
- Not stated
Inclusion 6
- Minimum age: 50 years
- Maximum age: 85 years
- Study condition: Alzheimer Disease, Image
- Patients aged ≥50 and ≤85 years old, male or female;
- Meet the diagnostic criteria for dementia or MCI;
- Neuropsychological score: MMSE 15-28 points, CDR ≤ 1 point; ④ Patients and their families are informed and sign the informed consent form
Exclusion 7
- The presence of other neurological diseases that may cause brain dysfunction (such as depression, brain tumors, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.);
- The presence of other systemic diseases that may cause cognitive impairment (such as liver dysfunction, renal dysfunction, thyroid dysfunction, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.);
- Suffering from a disease that makes it impossible to cooperate with cognitive examinations;
- The presence of contraindications to MRI;
- The presence of mental and neurological retardation;
- Refusing to draw blood;
- Refusing to sign the informed consent form.
Where
8 sites, 8 recruiting
Chinese People's Liberation Army General Hospital
Beijing, Beijing Municipality, China
Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine
Cangzhou, Hebei, China
First Affiliated Hospital of Zhejiang University School of Medicine
Hanzhong, Hangzhou, China
Qilu Hospital of Shandong University, Qingdao Branch
Qingdao, Shandong, China
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
and 2 more sites on ClinicalTrials.gov
Contact
-
Jintao Wang
18221457023 jt_wang@sjtu.edu.cn
Potential match only. Final eligibility is determined by the study team.