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EMVI as a Determinant of Metastasis in Colorectal Cancer

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About this study

Bowel cancer is the fourth most commonly occurring cancer and the second highest cause of cancer deaths in the UK. Despite advances in treatment, over 40% of patients will die within 5 years. This is normally due to spread of the cancer to other organs (called metastases). Much of the current research focuses on use of additional treatments such as radiotherapy and chemotherapy before or after surgery (adjuvant treatment). It is of vital importance that patients who would benefit from adjuvant treatment can be accurately identified. At the moment, the system used locally to do this places emphasis on the presence of affected lymph nodes (glands). This is because doctors believe that cancer spreads to other organs through the lymphatic system. However, recent studies have suggested that this is not the case. It is believed that cancer spreads to other organs through the blood stream rather than the lymph node system. This research will look at the genetic material in tumours and metastases as well as in areas of blood vessel invasion and lymph nodes. The analysis will allow us to build a 'family tree' of the tumour and allow us to map the pathway by which the tumour spreads. Tissue samples already collected through a patient's routine care will be used for this study. If the spread through the blood vessels is proven, this would change the way in which patients are selected for treatment and allow development of new treatments to target these pathways.

Condition
Colo-rectal Cancer
Sponsor
Imperial College London

Who can join

Age
16 to 100 years
Sex
All sexes
Healthy volunteers
Not stated

Inclusion 7

  • Minimum age: 16 years
  • Maximum age: 100 years
  • Study condition: Colo-rectal Cancer
  • Are aged 16 years or over with colorectal cancer
  • Colon / rectum has been surgically removed
  • Distant metastases has been surgically removed
  • Pre operative staging in the form of CT/MRI has been undertaken and images available for review

Exclusion 3

  • Pathological complete response in the primary tumour
  • Local resection of the primary tumour
  • Inadequate quantity of tissue sample to perform analyses

Where

1 site, 1 recruiting

Hampshire Hospitals Nhs Foundation Trust

Basingstoke, Hampshire, United Kingdom

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.