Pilot Study "AHSP as a Biomarker of Sickle Cell Disease in a Population of Adults and Children"
About this study
Evaluation of AHSP concentration in total blood as a biomarker in adult and pediatric sickle cell patients
- Condition
- in Relation to Sickle Cell Disease
- Tested
- Measurement of AHSP concentration
- Sponsor
- Centre Hospitalier de Saint-Denis
Who can join
- Age
- 3 years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 8
- Minimum age: 3 years
- Study condition: in Relation to Sickle Cell Disease
- Adults: \> 15 years and 6 months
- Pediatrics: ≥ 3 years and ≤ 15 years and 6 months
- Known SS or Sβ0 phenotypes
- -Adults: \> 15 years and 6 months /Pediatrics: ≥ 3 years and ≤ 15 years and 6 months 2-Absence of Hemoglobinopathy 3-Follow-up for one of the following conditions (adults): Evaluation of hematological disease excluding hemoglobinopathy, evaluation of prolonged fever or inflammatory syndrome, initial or episodic evaluation of an auto-inflammatory disease or systemic disease, general health deterioration
- Follow-up for one of the following conditions (pediatrics): Suspected precocious puberty, growth delay, or neurodevelopmental disorder
- Blood sample planned as part of medical care
Exclusion 11
- Hemoglobin disorder other than sickle cell disease (Criteria for Sickle Cell Patients)
- Hemoglobinopathies other than sickle cell disease (Criteria for Control Patients)
- Transfusion less than 3 months ago
- Chronic active viral disease: hepatitis B, C, HIV
- Current infections or known inflammatory pathologies
- Known hyper or hypothyroidism or subject treated with levothyroxine
- Active tumor pathology or remission for less than 5 years
- Oral corticosteroid therapy in progress
- Participation in interventional biomedical research
- Opposition to participation in research by the patient if he is an adult, or by one of the two parents if the patient is a minor.
- Non-affiliation to a social security system
Where
1 site, 1 recruiting
Centre Hospitalier de Saint-Denis
Saint-Denis, France
Contact
-
Stéphanie NGO, Coordinating Investigator
stephanie.ngo@ch-stdenis.fr stephanie.ngo@ch-stdenis.fr
-
Stéhanie COSSEC, Project Coordinator
stephanie.cossec@ghtpdfr.fr stephanie.cossec@ghtpdfr.fr
Potential match only. Final eligibility is determined by the study team.