Forearm Immobilization in T2D
About this study
The aim of the present study is to assess the impact of short-term forearm immobilization on forearm muscle glucose uptake and amino acid net balance and kinetics in individuals with T2D compared with a control group with normoglycaemia.
- Condition
- Healthy, Type 2 Diabetes
- Tested
- Forearm immobilization
- Sponsor
- Wageningen University
Who can join
- Age
- 18 to 80 years
- Sex
- All sexes
- Healthy volunteers
- Accepted
Inclusion 7
- Minimum age: 18 years
- Maximum age: 80 years
- Study condition: Healthy, Type 2 Diabetes
- Males and females with or without diagnosed type 2 diabetes
- Use lifestyle changes, metformin, gliclazide, or a combination thereof as oral glucose-lowering treatments for T2D
- Aged 18-80 years at the time of signing informed consent
- 18.5 ≥ BMI ≤ 35 kg·m2
Exclusion 16
- Type 1 or a genetic form of diabetes
- Any diagnosed cardiovascular (heart) disease or high blood pressure (≥160 mmHg systolic and/or ≥100 mmHg diastolic)
- Chronic use of any prescribed or over-the-counter pharmaceuticals (excluding oral contraceptives and contraceptive devices) that interact with muscle substrate metabolism (e.g. selective serotonin reuptake inhibitors)
- Consumption of a low-carbohydrate diet
- Smoking or chewing tobacco
- Known anaemia
- Regular use of dietary protein and/or amino acid supplements (\>3 times per week)
- Currently involved in a structured progressive resistance training program (\>3 times per week)
- A personal or family history of thrombosis (clots)
- Any previous motor disorders or inborn errors in muscle and/or lipid metabolism
- History of kidney disease
- History of liver disease
- Pregnant or breastfeeding
- History of any drug or alcohol abuse in the past two years
- Claustrophobia
- Unable to give consent
Where
1 site, 1 recruiting
Wageningen University and Research
Wageningen, Gelderland, Netherlands
Contact
-
Marlou Dirks, PhD
+31 317 480 100 marlou.dirks@wur.nl
Potential match only. Final eligibility is determined by the study team.