Advances in Imaging to Assess Response in Rectal Cancer
About this study
The goal of this observational study is to determine the feasibility of acquiring serial MRI images for advanced radiotherapy planning in colorectal patients. The main question it aims to answer: Is it feasible to acquire serial MR images for advanced radiotherapy planning for rectal cancer.
- Condition
- Colorectal Cancer (CRC)
- Tested
- Observational single centre feasibility study
- Sponsor
- NHS Greater Glasgow and Clyde
Who can join
- Age
- 18 years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 8
- Minimum age: 18 years
- Study condition: Colorectal Cancer (CRC)
- Histologically confirmed rectal adenocarcinoma.
- T stage 3b or above and/or high risk factors eg. EMVI, nodal disease.
- Participant able to give written informed consent.
- Male or non-pregnant female ≥18 years of age.
- Scheduled to undergo radical radiotherapy.
- Patients willing and able to comply with the protocol for the duration of study.
Exclusion 7
- Contra-indications to MRI, such as claustrophobia, excessive body weight, MRI unsafe implants, ferrous metal in the body, insufficient information on prior surgeries. MRI conditional implants where conditions cannot be met (e.g pacemakers).
- Any previous radiotherapy to the pelvis.
- Inflammatory bowel disease.
- Other severe or uncontrolled systemic disease or evidence of any other significant disorder or lab finding that makes it undesirable for the patient to participate in the study, as determined by the treating clinician.
- History of physical or psychiatric disorder that would prevent informed consent and compliance with the protocol.
- Patients with de-functioning stoma.
- Major surgery within 28 days prior to trial entry.
Where
1 site, 1 recruiting
Beatson West of Scotland Cancer Centre
Glasgow, United Kingdom
Contact
-
Ms Lynsey Devlin
0141 301 9902 lynsey.devlin@nhs.scot
-
Ms Aileen Duffton, PhD Cancer Sciences
0141 301 7428 Aileen.duffton@nhs.scot
Potential match only. Final eligibility is determined by the study team.