CAR2219 CAR-T Cells for the Treatment of R/R B Cell Leukemia...

About this study

This is a single arm study to evaluate the safety and efficacy of CAR2219 CAR-T cells in the treatment of relapsed/refractory CD19/CD22 positive B cell Leukemia and Lymphoma.

Condition: Relapsed or Refractory B Cell Leukemia and Lymphoma
Tested: CAR2219-T cells
Sponsor: Affiliated Hospital to Academy of Military Medical Sciences

Who can join

Age: 14 to 75 years
Sex: All sexes
Healthy volunteers: Not accepted

Inclusion 15

Minimum age: 14 years
Maximum age: 75 years
Study condition: Relapsed or Refractory B Cell Leukemia and Lymphoma
Signed written informed consent;
Relapsed/refractory CD19/CD22 positive B cell Leukemia or Lymphoma must be assured and meet one of the following conditions: (1) Confirmation for either CD19 or CD22 positivity using immunohistochemistry or flow cytometry;
(2) B-cell tumors include the following three categories: ① B-cell acute lymphoblastic leukemia (B-ALL);
Indolent B-cell lymphoma (CLL, FL, MZL, LPL, HCL);
Aggressive B-cell lymphoma (DLBCL, BL, MCL) (3) Refractory/recurrent B-ALL (include one of the following situations) : ① relapse within 12 months after the first remission; ② The first refractory patients who did not achieve complete remission after 2 cycles of standard chemotherapy regimen; ③ Failure to achieve complete remission or relapse after first-line or multi-line salvage chemotherapy; ④ Recurrence after hematopoietic stem cell transplantation.
(4) Refractory/recurrent B-cell lymphoma (meeting the requirements of 1 of the first 4 below plus 5) : ① After 4 courses of chemotherapy prescribed by the standard protocol, the tumor has shrunk by less than 50% or the disease progression(PD); ② CR reached after standard chemotherapy, but relapse occurred within 12 months; ③ Two or more recurrence after CR; ④ Recurrence after hematopoietic stem cell transplantation; ⑤Patients must have received rituximab or another anti-CD20 monoclonal antibody (unless Investigator determines that tumor is CD20-negative) and an anthracycline-containing chemotherapy regimen.
All genders, ages: 14 to 75 years
Eastern Cooperative Oncology Group (ECOG) Performance Status 0 to 2.
Life expectancy ≥3 months;
HGB≥70g/L
Liver,kidney function and cardiopulmonary function meet the following requirements: (1) creatinine ≤1.5×ULN; (2) left ventricular ejection fraction≥50%; (3) Oxygen saturation \>90%; (4) Total bilirubin ≤1.5×ULN, ALT and AST≤2.5×ULN;
Participants agreed to use contraception from the time of informed consent until 1 year after CAR-T cell infusion."

Exclusion 10

Severe heart failure with left ventricular ejection fraction \<50%;
A history of severe lung function impairment;
Combined with other advanced malignant tumors;
Complicated with severe infection that could not be effectively controlled;
Severe autoimmune disease or congenital immune deficiency;
Active hepatitis (hepatitis B virus DNA \[HBV-DNA\] or hepatitis C virus RNA \[HCV-RNA\] test results above the lower limit of detection);
Human immunodeficiency virus (HIV) infection or known acquired immunodeficiency syndrome (AIDS), or syphilis infection;
History of severe allergy to biological products (including antibiotics);
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients with acute graft-versus-host reaction (GVHD) one month after immunosuppressant withdrawal;
Patients with other serious physical or mental illnesses or laboratory abnormalities that could increase the risk of participating in the study or interfere with the results of the study, and those who were deemed by the investigator to be unsuitable for participation in the study.

Where

1 site, 1 recruiting

the Fifth Medical Center of Chinese People's Liberation Army General Hospital

Beijing, Beijing Municipality, China

Recruiting

Contact