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Recruiting Phase 1

Phase 1 Study of AUTX-703 in Relapsed/Refractory AML and MDS

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About this study

This Phase 1, multicenter, open-label, dose escalation and dose optimization study is designed to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary clinical activity of AUTX-703 administered orally in subjects with advanced hematologic malignancies.

Condition
Relapsed Acute Myeloid Leukemia (AML), Refractory Acute Myeloid Leukemia (AML), Relapsed/Refractory AML, Relapsed Myelodysplastic Syndromes, Refractory Myelodysplastic Syndromes, Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)
Tested
AUTX-703
Sponsor
Auron Therapeutics, Inc.

Who can join

Age
18 years and older
Sex
All sexes
Healthy volunteers
Not accepted

Inclusion 15

  • Minimum age: 18 years
  • Study condition: Relapsed Acute Myeloid Leukemia (AML), Refractory Acute Myeloid Leukemia (AML), Relapsed/Refractory AML, Relapsed Myelodysplastic Syndromes, Refractory Myelodysplastic Syndromes, Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)
  • Participant must be ≥18 years of age
  • Participant must have confirmed diagnosis as follows:
  • R/R AML and has not achieved adequate response to, or cannot tolerate, all approved therapies known to be active for treatment of their disease OR R/R MDS with over 10% blasts in the bone marrow and has not achieved an adequate response to at least 4 cycles of a hypomethylating agent (HMA)- containing regimen or other treatment known to be active for their disease OR R/R AML or R/R MDS that has relapsed after a hematopoietic stem cell transplant (HSCT)
  • Participant must be willing and able to comply with scheduled study visits and treatment plans.
  • Participant must be willing to undergo all study procedures unless contraindicated due to medical risk.
  • Participant must have an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0-1
  • Participant must have adequate hepatic function
  • Participant must have adequate renal function
  • Participant must have adequate cardiovascular function
  • Participant must have a white blood cell (WBC) count ≤20 × 10⁹/L (with stable hydroxyurea use allowed)
  • Participant must meet timing requirements with respect to prior therapy and surgery
  • Participant must agree to use effective contraception during the study and for the required post-treatment period: Males: Use condoms (even if vasectomized) during the study and for 90 days post-treatment.
  • Females of childbearing potential: Use a combination of 1 highly effective and 1 effective method of contraception during the study and for 180 days post-treatment.

Exclusion 15

  • Participant is unable to provide informed consent and/or to follow protocol requirements.
  • Participant has undergone chimeric antigen receptor T cell therapy or HSCT within 60 days of the first dose of study treatment or has active clinically significant graft-versus-host disease (GVHD)
  • Participant has another malignancy that may interfere with diagnosis and treatment of R/R AML or R/R MDS.
  • Participant has an active severe infection that requires anti-infective therapy or has an unexplained temperature of \>38.5°C during screening visits or on their first day of study treatment.
  • Participant has a known sensitivity to AUTX-703 or any of its components.
  • Participant is taking systemic strong CYP3A4 inhibitors or inducers within 14 days of the first dose of study treatment.
  • Participant who are taking proton pump inhibitors should be switched to another acid-reducing agent such as an antacid or H2 blocker
  • Participant is taking P-gp and breast cancer resistance protein (BCRP) inhibitors or inducers within 14 days of first dose of study treatment.
  • Participant has active hepatitis B virus (HBV) or hepatitis C virus (HCV) infections with detectable viral load
  • Participant has experienced AIDS related illness within the past 6 months or have detectable HIV viral load.
  • Participant has an uncontrolled intercurrent illness
  • Participant has active Class III or IV cardiovascular disease within 6 months prior to the start of study treatment
  • Participant is unable to tolerate the administration of oral medication or has GI dysfunction that would preclude adequate absorption, distribution, metabolism, or excretion of an oral medication
  • Participant is pregnant or breastfeeding or is planning to become pregnant within 1 year of the start of study treatment
  • Have a history of interstitial lung disease or pneumonitis.

Where

9 sites, 5 recruiting

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, United States

Recruiting

Ohio State University, The James Comprehensive Cancer

Columbus, Ohio, United States

Recruiting

City of Hope National Medical Center

Duarte, California, United States

Recruiting

Sarah Cannon Center for Blood Cancer at TriStar Centennia

Nashville, Tennessee, United States

Recruiting

UPENN Perelman Center for Advanced Medicine

Philadelphia, Pennsylvania, United States

Recruiting

Roswell Park Comprehensive Cancer Center

Buffalo, New York, United States

and 3 more sites on ClinicalTrials.gov

Contact

Potential match only. Final eligibility is determined by the study team.